Rediscovering area CA2: unique properties and functions.
Rediscovering area CA2: unique properties and functions.
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DOI：
10.1038/nrn.2015.22
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发表时间：
2016-02
期刊：
影响因子：
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通讯作者：
Farris S
中科院分区：
文献类型：
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作者：
Dudek SM;Alexander GM;Farris S
海马区 CA2 有几个区别于 CA1 和 CA3 的特征，包括独特的基因表达谱、无法表现出长期增强作用以及对细胞死亡的相对抵抗力。最近人们对 CA2 区域的兴趣增加，加上定义和操纵其神经元的新方法的开发，导致了关于 CA2 神经元的特性及其在行为中的作用的一些令人兴奋的新发现。在这里，我们回顾这些发现，并提请人们注意 CA2 区的定义应该根据基因表达数据进行修订的想法。
Hippocampal area CA2 has several features that distinguish it from CA1 and CA3, including a unique gene expression profile, failure to display long-term potentiation and relative resistance to cell death. A recent increase in interest in the CA2 region, combined with the development of new methods to define and manipulate its neurons, has led to some exciting new discoveries on the properties of CA2 neurons and their role in behaviour. Here, we review these findings and call attention to the idea that the definition of area CA2 ought to be revised in light of gene expression data.