DENDRITIC REGRESSION DISSOCIATED FROM NEURONAL DEATH BUT ASSOCIATED WITH PARTIAL DEAFFERENTATION IN AGING RAT SUPRAOPTIC NUCLEUS
DENDRITIC REGRESSION DISSOCIATED FROM NEURONAL DEATH BUT ASSOCIATED WITH PARTIAL DEAFFERENTATION IN AGING RAT SUPRAOPTIC NUCLEUS
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DOI：
10.1016/0197-4580(93)90042-a
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发表时间：
1993-11-01
影响因子：
4.2
通讯作者：
COLEMAN, PD
中科院分区：
文献类型：
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作者：
FLOOD, DG;COLEMAN, PD
当神经元在正常老化中丢失时，存活的相邻神经元的树突可能增殖、退化或保持不变。在与年龄相关的树突退化的情况下，很难区分退化是否先于神经元死亡，或者是否是传入供应丧失的结果。大鼠视上核（SON）代表了一个模型系统，其中没有与年龄相关的神经元损失，但其中有一个与年龄相关的传入损失。在3、12、20、27、30和32月龄的雄性Fischer 344大鼠中研究了SON的大细胞神经分泌神经元，其产生垂体后叶中的加压素和催产素以供释放。Nissl染色切片中的计数显示没有神经元随年龄增长而丢失，并证实了其他品系大鼠以及小鼠和人类中的类似发现。核仁大小增加3和12个月的年龄之间，部分原因是核仁融合，并在12和32个月的年龄之间没有变化，表明在老年维持一般细胞功能。高尔基体染色组织中量化的树突程度在3至12个月龄之间增加，在12至20个月龄之间稳定，在20至27个月龄之间减少。我们将3至12个月之间的增长解释为后期成熟的变化。20和27个月之间的树突退化可能是由于去甲肾上腺素能输入到SON的腹侧髓质的先前年龄相关的损失deafferentation的结果。
As neurons are lost in normal aging, the dendrites of surviving neighbor neurons may proliferate, regress, or remain unchanged. In the case of age-related dendritic regression, it has been difficult to distinguish whether the regression precedes neuronal death or whether it is a consequence of loss of afferent supply. The rat supraoptic nucleus (SON) represents a model system in which there is no age-related loss of neurons, but in which there is an age-related loss of afferents. The magnocellular neurosecretory neurons of the SON, that produce vasopressin and oxytocin for release in the posterior pituitary, were studied in male Fischer 344 rats at 3, 12, 20, 27, 30, and 32 months of age. Counts in Nissl-stained sections showed no neuronal loss with age, and confirmed similar findings in other strains of rat and in mouse and human. Nucleolar size increased between 3 and 12 months of age, due, in part, to nucleolar fusion, and was unchanged between 12 and 32 months of age, indicating maintenance of general cellular function in old age. Dendritic extent quantified in Golgi-stained tissue increased between 3 and 12 months of age, was stable between 12 and 20 months, and decreased between 20 and 27 months. We interpret the increase between 3 and 12 months as a late maturational change. Dendritic regression between 20 and 27 months was probably the result of deafferentation due to the preceding age-related loss of the noradrenergic input to the SON from the ventral medulla.