Genetic variation of polygenic characters and the evolution of genetic degeneracy
Genetic variation of polygenic characters and the evolution of genetic degeneracy
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DOI：
10.1046/j.1420-9101.2003.00485.x
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发表时间：
2003-01-01
影响因子：
2.1
通讯作者：
Frank, SA
中科院分区：
文献类型：
--
作者：
Frank, SA
数量性状的经典突变-选择平衡模型是将单个位点的效应加总以确定总体性状值。我开发了一个替代版本的这个经典模型中，字符值取决于平均的影响，个别网站。在这个新的平均模型中，等位基因效应和字符值的方差的平衡模式随着影响字符的位点的数量而变化，其方式与经典的求和效应模型不同。除了改变方差的模式，平均模型有利于增加基因座控制的字符值，也许部分解释了最近观察到的广泛遗传退化。
The classical model of mutation - selection balance for quantitative characters sums the effects of individual sites to determine overall character value. I develop an alternative version of this classical model in which character value depends on the averaging of the effects of the individual sites. In this new averaging model, the equilibrium patterns of variance in allelic effects and character values change with the number of sites that affect a character in a different way from the classical model of summing effects. Besides changing the patterns of variance, the averaging model favours the addition of loci to the control of character values, perhaps explaining in part the recent observation of widespread genetic degeneracy.