Persistent Luminescent Nanocarrier as an Accurate Tracker in Vivo for Near Infrared-Remote Selectively Triggered Photothermal Therapy
Persistent Luminescent Nanocarrier as an Accurate Tracker in Vivo for Near Infrared-Remote Selectively Triggered Photothermal Therapy
复制标题
持久发光纳米载体作为体内近红外远程选择性触发光热治疗的精确跟踪器
DOI：
10.1021/acsami.6b07642
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发表时间：
2016
影响因子：
9.5
通讯作者：
Chang Jin
中科院分区：
文献类型：
--
作者：
Zheng Bin;Chen Hong-bin;Zhao Pei-qi;Pan Hui-zhuo;Wu Xiao-li;Gong Xiao-qun;Wang Han-jie;Chang Jin
吲哚菁绿色（ICG）光成像引导光热治疗（PTT）在肿瘤治疗中具有巨大潜力。然而，传统的光学图像引导模式导致活体组织产生强烈的组织自发荧光，导致无法进行准确的红外光照射。本文首次设计并制备了ICG和长余辉发光材料（PLPs）共掺杂介孔二氧化硅纳米载体（（ICG+PLPs）@mSiO2），用于长余辉发光成像引导的PTT。（ICG+PLPs）@mSiO2纳米载体可以显著提高发光成像引导PTT过程中的信噪比，使PLP有望提高体内光热治疗肿瘤部位的准确性。本论文有望开发一种基于近红外（NIR）远程选择性触发发光成像引导PTT的精确调控癌细胞死亡的新途径。
Optical imaging-guidance of indocyanine green (ICG) for photothermal therapy (PTT) has great latent capacity in cancer therapy. However, the conventional optical image-guidance mode has caused strong tissue autofluorescence of the living tissue, which leads to the accurate infrared light irradiation cannot be conducted. In this article, ICG and persistent luminescence phosphors (PLPs) coloaded mesoporous silica nanocarriers ((ICG+PLPs)@mSiO2) were first designed and prepared for persistent luminescent imaging-guided PTT. The (ICG+PLPs)@mSiO2nanocarriers could significantly improve signal-to-noise ratio during luminescence imaging-guided PTT, making the PLP promising for improving the accuracy of the tumor site for photothermal therapy in vivo. This paper is likely to develop a new way for accurately regulating cancer cell death based on luminescence imaging-guided PTT selectively triggered by near-infrared (NIR)-remote.