Corticotropin-releasing hormone inhibits maternal behavior and induces pup-killing.
Corticotropin-releasing hormone inhibits maternal behavior and induces pup-killing.
复制标题
促肾上腺皮质激素释放激素抑制母体行为并诱导幼崽死亡。
DOI：
10.1016/0024-3205(91)90278-j
复制
发表时间：
1991
期刊：
影响因子：
6.1
通讯作者：
Evans,DL
中科院分区：
文献类型：
--
作者：
Pedersen,CA;Caldwell,JD;McGuire,M;Evans,DL
压力源的行为反应及压力源对母亲行为的影响随母亲教养经验而改变。促肾上腺皮质激素释放激素（CRH）是由应激源释放，并产生类似压力的行为效应。我们测试了ICV输注绵羊CRH（0.5-4 μ g）对卵巢切除、卵巢类固醇治疗的未交配大鼠（未接触幼崽或有3天育儿经验）的幼崽定向行为的影响。CRH以剂量相关的方式抑制幼稚和经验大鼠的母性行为。在有育儿经验的大鼠中，抑制的幅度和持续时间较小，尤其是在1 ug剂量下。较高剂量的CRH（1 - 4 μ g）显著增加了未接触幼鼠的大鼠杀死幼鼠的行为。相比之下，CRH在有母性经验的大鼠中不产生杀婴作用。
Behavioral responses to stressors and the effects of stressors on maternal behavior change with mothering experience. Corticotropin-releasing hormone (CRH) is released by stressors and produces stress-like behavioral effects. We tested the effects of ICV infusion of ovine CRH (0.5–4 ug) on pup-directed behaviors in ovariectomized, ovarian steroid-treated virgin rats that were either naive to pups or that had three days of mothering experience. CRH inhibited maternal behavior in naive and experience rats in a dose-related manner. The magnitude and duration of inhibition, especially at the 1 ug dose, were less in rats with mothering experience. Higher doses of CRH (1 – 4 ug) significantly increased pup-killing in rats that were naive to pups. In contrast, CRH produced no pup-killing in rats with mothering experience.