A Conscious Resting State fMRI Study in SLE Patients Without Major Neuropsychiatric Manifestations
A Conscious Resting State fMRI Study in SLE Patients Without Major Neuropsychiatric Manifestations
复制标题
一项针对无主要神经精神表现的 SLE 患者的清醒静息态功能磁共振成像研究。
DOI：
10.3389/fpsyt.2018.00677
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发表时间：
2018-12-07
影响因子：
4.7
通讯作者：
Xu, Jian
中科院分区：
文献类型：
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作者：
Liu, Shuang;Cheng, Yuqi;Xu, Jian
神经精神性系统性红斑狼疮(NPSLE)是系统性红斑狼疮(SLE)患者的主要死亡原因之一。NPSLE的症状和体征多种多样，早期诊断和治疗困难。本研究旨在利用静息状态功能磁共振成像技术，探讨无主要神经精神症状的SLE患者(非NPSLE患者)的脑活动变化。我们还试图调查大脑活动、疾病活动、抑郁和焦虑之间的可能联系。在我们的研究中，118名非NPSLE患者和81名健康对照(HC)被纳入研究。使用RS-fMRI数据计算所有受试者的区域均匀度(REHO)。我们发现梭形回和丘脑的ReHO值降低，而海马旁回和钩状回的ReHO值增加。疾病活动性与小脑ReHO值呈正相关，与额回ReHO值呈负相关。大脑的几个区域显示出与抑郁和焦虑状态相关。这些结果提示，脑活动异常可能发生在NPSLE之前，并可能是焦虑和抑郁症状的基础。早期发现和适当治疗脑功能障碍可能会阻止进展为NPSLE。需要更多的研究来了解复杂的潜在机制。
Neuropsychiatric systemic lupus erythematosus (NPSLE) is one of the main causes of death in patients with systemic lupus erythematosus (SLE). Signs and symptoms of NPSLE are heterogeneous, and it is hard to diagnose, and treat NPSLE patients in the early stage. We conducted this study to explore the possible brain activity changes using resting state functional magnetic resonance imaging (rs-fMRI) in SLE patients without major neuropsychiatric manifestations (non-NPSLE patients). We also tried to investigate the possible associations among brain activity, disease activity, depression, and anxiety. In our study, 118 non-NPSLE patients and 81 healthy controls (HC) were recruited. Rs-fMRI data were used to calculate the regional homogeneity (ReHo) in all participants. We found decreased ReHo values in the fusiform gyrus and thalamus and increased ReHo values in the parahippocampal gyrus and uncus. The disease activity was positively correlated with ReHo values of the cerebellum and negatively correlated with values in the frontal gyrus. Several brain areas showed correlations with depressive and anxiety statuses. These results suggested that abnormal brain activities might occur before NPSLE and might be the foundation of anxiety and depression symptoms. Early detection and proper treatment of brain dysfunction might prevent the progression to NPSLE. More studies are needed to understand the complicated underlying mechanisms.