TMS interferes with lexical-semantic retrieval in left inferior frontal gyrus and posterior middle temporal gyrus: Evidence from cyclical picture naming
TMS interferes with lexical-semantic retrieval in left inferior frontal gyrus and posterior middle temporal gyrus: Evidence from cyclical picture naming
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DOI：
10.1016/j.neuropsychologia.2014.09.014
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发表时间：
2014-11-01
期刊：
影响因子：
2.6
通讯作者：
Jefferies, Elizabeth
中科院分区：
文献类型：
--
作者：
Krieger-Redwood, Katya;Jefferies, Elizabeth
本研究采用经颅磁刺激（TMS）研究了左额下回（LIFG）和颞中后回（pMTG）在循环命名范式下对词汇/语义选择和提取过程的作用。参与者命名的图片，在六个周期中反复呈现，无论是在语义相关或不相关的集。以前的研究表明，选择要求更高的相关集，特别是在重复后，因为参与者的经验竞争激活语义邻居。与此相反，检索要求更大的不相关的集合在语义启动的情况下，特别是在第一个周期时，目标名称尚未被激活。因此，这种范式可以揭示（i）检索需求（即，从视觉输入访问图片名称的容易性）和（ii）选择/竞争。我们发现，rTMS LIFG和pMTG产生了类似的行为效应：这两个网站的刺激破坏图片命名性能的早期周期（当参与者在生产的图片名称较少练习）和语义相关的集（当有可能增加竞争，但也促进语义邻居）。当检索或选择要求最大时，TMS没有影响。因此，数据支持的观点，LIFG和pMTG有助于图片名称检索，这两个网站发挥了关键作用，在调解的语义促进命名时，检索要求很高。(C)2014爱思唯尔有限公司版权所有。
We used TMS to investigate the contribution of left inferior frontal gyrus (LIFG) and posterior middle,temporal gyrus (pMTG) to lexical/semantic selection and retrieval processes using a cyclical naming paradigm. Participants named pictures that were presented repeatedly across six cycles, either in semantically related or unrelated sets. Previous research has suggested that selection demands are higher for related sets, especially after repetition, since participants experience competition from the activation of semantic neighbours. In contrast, retrieval demands are greater for unrelated sets in the absence of semantic priming, particularly on the first cycle when the target names have not been previously activated. Therefore, this paradigm can reveal independent effects of (i) retrieval demands (i.e., the ease of accessing picture names from visual input) and (ii) selection/competition. We found that rTMS to LIFG and pMTG produced similar behavioural effects: stimulation of both sites disrupted picture naming performance on early cycles (when participants were less practised at producing the picture names) and for semantically-related sets (when there was the potential for increased competition and yet also facilitation from semantic neighbours). There were no effects of TMS when either retrieval or selection requirements were maximal on their own. The data therefore support the view that both LIFG and pMTG contribute to picture name retrieval, with both sites playing a critical role in mediating the semantic facilitation of naming when retrieval demands are high. (C) 2014 Elsevier Ltd. All rights reserved.