The manifold actions of endocannabinoids on female and male reproductive events
The manifold actions of endocannabinoids on female and male reproductive events
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DOI：
10.2741/3701
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发表时间：
2011-01-01
影响因子：
3.1
通讯作者：
Maccarrone, Mauro
中科院分区：
文献类型：
--
作者：
Bari, Monica;Battista, Natalia;Maccarrone, Mauro
流行病学研究强调青少年使用非法药物的情况日益增多。年轻人对大麻（大麻提取物）对生殖健康的负面影响知之甚少，尽管长期接触大麻的主要精神活性成分 delta-9-四氢大麻酚会扰乱女性的月经周期、抑制卵子生成、损害胚胎植入和发育，以及增加射精问题、减少精子数量和活力、导致性欲丧失和阳痿，从而损害人类生殖潜力。在男性中。内源性大麻素、其代谢酶和靶受体形成所谓的“内源性大麻素系统”，并且它们已被证明能够对生育信号做出反应。此外，它们还会干扰女性和男性生殖事件中的激素、细胞因子和其他信号分子。在这篇综述中，我们将总结目前关于内源性大麻素系统的知识，以及内源性大麻素在从无脊椎动物到哺乳动物的进化轴的繁殖中所发挥的多方面作用。此外，我们将讨论内源性大麻素系统的不同元素在诊断和/或治疗人类不育症中的潜在用途。
Epidemiological studies have highlighted the ever growing use of illegal drugs among teenagers. The negative effects of marijuana (a Cannabis sativa extract) on reproductive health are poorly known among young people, although chronic exposure to delta-9-tetrahydrocannabinol, the main psychoactive constituent of marijuana, impairs human reproductive potential by disrupting menstrual cycle, suppressing oogenesis and impairing embryo implantation and development, in women, and by increasing ejaculation problems, reducing sperm count and motility, and generating loss of libido and impotence, in men. Endocannabinoids, their metabolic enzymes and target receptors form the so called "endocannabinoid system" and they have been demonstrated to respond to fertility signals. In addition, they interfere with hormones, cytokines and other signalling molecules in both female and male reproductive events. In this review, we shall summarize the current knowledge on the endocannabinoid system, and on the multifaceted roles played by endocannabinoids in reproduction along the evolutionary axis from invertebrates to mammals. Furthermore, we shall discuss the potential use of distinct elements of the endocannabinoid system for the diagnosis and/or treatment of human infertility.