A HYPOTHESIS ON THE CAUSE OF CHRONIC EPIDERMAL HYPERPROLIFERATION IN ASEBIA MICE
A HYPOTHESIS ON THE CAUSE OF CHRONIC EPIDERMAL HYPERPROLIFERATION IN ASEBIA MICE
复制标题
DOI：
10.1111/j.1365-2230.1988.tb00661.x
复制
发表时间：
1988-03-01
影响因子：
4.1
通讯作者：
HARDY, MH
中科院分区：
文献类型：
--
作者：
BROWN, WR;HARDY, MH
本文对突变型小鼠asebia（ab/ab）与正常BALB/c小鼠皮肤进行了真皮细胞计数、表皮厚度、表皮细胞标记指数和超微结构的比较。在asebia中，我们发现表皮过度增生和真皮炎症，真皮中有许多细胞碎片。大量的巨噬细胞，无论是完整的还是正在分解的，都含有电子透明的晶体，显然是由脂质组成的。我们假设这些晶体引起巨噬细胞溶解，随后是皮肤炎症，最后是表皮过度增殖。
We compared the skin of the mutant mouse asebia (ab/ab) with that of normal BALB/c mice by examining dermal cell counts, epidermal thickness, epidermal cell labelling index and ultrastructure. In asebia we found epidermal hyperproliferation and dermal inflammation, with much cell debris in the dermis. The very numerous macrophages, both intact and disintegrating, contained electron-lucent crystals, apparently composed of lipid. We hypothesize that these crystals cause macrophage lysis followed by dermal inflammation and finally hyperproliferation in the overlying epidermis.