Adhesive, Flexible, and Robust Polysaccharide Nanosheets Integrated for Tissue-Defect Repair
Adhesive, Flexible, and Robust Polysaccharide Nanosheets Integrated for Tissue-Defect Repair
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DOI：
10.1002/adfm.200900103
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发表时间：
2009-08-24
影响因子：
19
通讯作者：
Takeoka, Shinji
中科院分区：
文献类型：
--
作者：
Fujie, Toshinori;Matsutani, Noriyuki;Takeoka, Shinji
纳米技术的最新发展导致了用于生产作为大分子组织的独立聚合物纳米片的方法。与本体膜相比，这种纳米片的大纵横比导致独特的物理性质，例如透明性、非共价粘合性和高柔性。在这里，报道了由生物相容性和可生物降解的多糖组成的聚合物纳米片的生物医学应用。微划痕和凸起测试表明，厚度为几十纳米的纳米片具有足够的物理粘附性和机械强度，可用于临床使用。将厚度为75 nm、临界载荷为9.1 × 10（4）Nm（-1）和弹性模量为9.6 GPa的纳米片用于小猎犬内脏胸膜缺损的微创修复，而没有任何由伤口修复引起的胸膜粘连。首次证明了基于分子组织的片状纳米生物材料的临床益处，这表明用于重叠组织伤口的新型治疗工具将是可能的，而不需要常规的手术干预。
Recent developments in nanotechnology have led to a method for producing free-standing polymer nanosheets as a macromolecular organization. Compared with bulk films, the large aspect ratio of such nanosheets leads to unique physical properties, such as transparency, noncovalent adhesion, and high flexibility. Here, a biomedical application of polymer nanosheets consisting of biocompatible and biodegradable polysaccharides is reported. Micro-scratch and bulge tests indicate that the nanosheets with a thickness of tens of nanometers have sufficient physical adhesiveness and mechanical strength for clinical use. A nanosheet of 75 nm thickness, a critical load of 9.1 x 10(4) N m(-1), and an elastic modulus of 9.6 GPa is used for the minimally invasive repair of a visceral pleural defect in beagle dogs without any pleural adhesion caused by wound repair. For the first time, clinical benefits of sheet-type nano-biomaterials based on molecular organization are demonstrated, suggesting that novel therapeutic tools for overlapping tissue wounds will be possible without the need for conventional surgical interventions.