Central tachykinins: mediators of defence reaction and stress reactions.
Central tachykinins: mediators of defence reaction and stress reactions.
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中枢速激肽：防御反应和应激反应的介质。
DOI：
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发表时间：
1995
影响因子：
2.1
通讯作者：
Thomas Unger
中科院分区：
文献类型：
--
作者：
J. Culman;Thomas Unger
速激肽P物质、神经激肽A和神经激肽B分别是NK 1、NK 2和NK 3受体的天然激动剂。来自生物化学、神经生理学、药理学和分子生物学研究的证据表明，脑内含有速激肽的通路有助于中枢心血管和内分泌调节以及运动活动的控制。下丘脑是中枢神经内分泌和自主神经过程整合的场所，富含速激肽神经末梢和速激肽受体。在清醒大鼠中刺激脑室周围或下丘脑NK 1受体可诱导综合性心血管、行为和内分泌反应。心血管反应与交感肾上腺活动增加有关，包括血压和心率增加、肠系膜和肾脏血管收缩以及后肢血管扩张。行为反应包括增加运动和梳理行为。这种反应模式与啮齿动物对伤害性刺激和疼痛的综合应激反应一致。一些研究表明，在急性应激后，不同脑区的P物质水平及其受体迅速变化。这些数据表明，P物质和其他速激肽，除了作为脊髓中的伤害性和疼痛递质外，还可能在大脑中作为神经递质-神经元回路中的神经调质，介导中枢应激反应。
The tachykinins substance P, neurokinin A, and neurokinin B are natural agonists for NK1, NK2, and NK3 receptors, respectively. Evidence from biochemical, neurophysiological, pharmacological, and molecular biology studies indicates that the tachykinin-containing pathways within the brain contribute to central cardiovascular and endocrine regulation and to the control of motor activity. The hypothalamus, which represents a site for the integration of central neuroendocrine and autonomic processes, is rich in tachykinin nerve endings and tachykinin receptors. Stimulation of periventricular or hypothalamic NK1 receptors in conscious rats induces an integrated cardiovascular, behavioural, and endocrine response. The cardiovascular response is associated with increased sympathoadrenal activity and comprises an increase in blood pressure and heart rate, mesenteric and renal vasoconstriction, and hind-limb vasodilatation. The behavioural response consists of increased locomotion and grooming behaviour. This response pattern is consistent with an integrated stress response to nociceptive stimuli and pain in rodents. Several studies have demonstrated rapid changes in substance P levels and its receptors in distinct brain areas following acute stress. These data indicate that substance P and other tachykinins, in addition to serving as nociceptive and pain transmitters in the spinal cord, may act in the brain as neurotransmitters--neuromodulators within the neuronal circuits mediating central stress responses.
影响因子：
21.1
作者：
M. Bannon;R. Roth
通讯作者：
M. Bannon;R. Roth