Gender differences in subjective stress and neuroendocrine response to a stress task among individuals with opioid dependence: A pilot study
Gender differences in subjective stress and neuroendocrine response to a stress task among individuals with opioid dependence: A pilot study
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DOI：
10.1016/j.addbeh.2018.12.022
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发表时间：
2019-05-01
影响因子：
4.4
通讯作者：
Back, Sudie E.
中科院分区：
文献类型：
--
作者：
Gilmore, Amanda K.;Guille, Constance;Back, Sudie E.
Background: Opioid dependence is a significant public health problem in the United States and the number of opioid overdose deaths among women has increased dramatically in comparison to men in the last few years. In this context, understanding the biological mechanisms underlying gender differences in vulnerability to opioid dependence is essential.Methods: The current pilot study examined gender differences in subjective stress, heart rate (HR), and cortisol/dephydroepiandrosterone (DHEA) response to a laboratory stressor (Trier Social Stress Test; TSST) or a no-stress condition, and drug cue paradigm among men (n = 21) and women (n = 18) with opioid dependence.Results: Significant group (TSST vs. no stress) differences emerged in self-reported stress [F(1,35) = 23.8, p
