Omega-3 Fatty acids could alleviate the risks of traumatic brain injury - a mini review.
Omega-3 Fatty acids could alleviate the risks of traumatic brain injury - a mini review.
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DOI：
10.4103/2225-4110.130374
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发表时间：
2014-04
影响因子：
4.5
通讯作者：
Manivasagam T
中科院分区：
文献类型：
--
作者：
Kumar PR;Essa MM;Al-Adawi S;Dradekh G;Memon MA;Akbar M;Manivasagam T
创伤性脑损伤（TBI）是一种获得性脑创伤，当任何突然的创伤/损伤导致脑损伤时发生。TBI的特征在于组织损伤和脑血流和代谢的不平衡。通过实验室实验已经确定，膳食补充ω-3脂肪酸（FA）可以减少由于TBI而在大脑中产生的氧化应激。在饮食中加入omega-3 FA可以使脑源性神经营养因子（BDNF）水平正常化，从而恢复神经细胞的存活。BDNF通过调节突触蛋白1和环磷酸腺苷（cAMP）反应元件结合蛋白来改善突触传递。补充ω-3多不饱和脂肪酸（PUFA）的TBI模型的脑组织分析显示脂质过氧化、核酸和蛋白质氧化显著降低，从而促进神经元和神经胶质细胞存活。因此，ω-3 FA摄入可以被认为是减少TBI引起的继发性神经元损伤的治疗选择。
Traumatic brain injury (TBI) is an acquired brain trauma that occurs when any sudden trauma/injury causes damage to the brain. TBI is characterized by tissue damage and imbalance in the cerebral blood flow and metabolism. It has been established through laboratory experiments that the dietary supplementation of omega-3 fatty acids (FAs) could reduce the oxidative stress developed in brain due to TBI. The inclusion of omega-3 FA in diet could normalize the levels of brain-derived neurotrophic factor (BDNF), and thus, it could restore the survival of neuronal cells. BDNF improves the synaptic transmission by regulating synapsin 1 and cyclic adenosine monophosphate (cAMP) response element binding protein. The brain tissue analysis of TBI models supplemented with omega-3 polyunsaturated fatty acids (PUFAs) showed significantly reduced lipid peroxidation, nucleic acid and protein oxidation, thereby promoting neuronal and glial cell survival. Thus, omega-3 FA intake could be considered as a therapeutic option to reduce the secondary neuronal damages initiated by TBI.