The Role of Stem Cells in Cutaneous Wound Healing: What Do We Really Know?
The Role of Stem Cells in Cutaneous Wound Healing: What Do We Really Know?
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DOI：
10.1097/prs.0b013e3181fbe2d8
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发表时间：
2011-01-01
影响因子：
3.6
通讯作者：
Longaker, Michael T.
中科院分区：
文献类型：
--
作者：
Ko, Sae Hee;Nauta, Allison;Longaker, Michael T.
创面修复是一个复杂的过程，涉及多种生长因子、细胞因子、趋化因子和细胞类型的协同作用。这一过程的失调会导致瘢痕疙瘩、增生性瘢痕和慢性不可愈合伤口等过度愈合的问题。这些问题具有广泛的全球影响。干细胞在促进损伤后的组织修复和再生方面具有巨大的潜力。干细胞生物学和皮肤组织工程领域的迅速发展为基于干细胞的创面修复疗法的发展创造了转化机会。(最后一次。重新构造手术127(补充)：10秒，2011年。)
Wound repair is a complex process involving the orchestrated interaction of multiple growth factors, cytokines, chemokines, and cell types. Dysregulation of this process leads to problems such as excessive healing in the form of keloids and hypertrophic scars and chronic, nonhealing wounds. These issues have broad global implications. Stem cells offer enormous potential for enhancing tissue repair and regeneration following injury. The rapidly developing fields of stem cell biology and skin tissue engineering create translational opportunities for the development of novel stem cell based wound-healing therapies. (Plast. Reconstr. Surg. 127 (Suppl.): 10S, 2011.)