Amount, type, and timing of recreational physical activity in relation to colon and rectal cancer in older adults: the Cancer Prevention Study II Nutrition Cohort.
Amount, type, and timing of recreational physical activity in relation to colon and rectal cancer in older adults: the Cancer Prevention Study II Nutrition Cohort.
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DOI：
10.1158/1055-9965.2187.13.12
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发表时间：
2004-12
期刊：
影响因子：
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通讯作者：
A. Chao;C. Connell;E. Jacobs;M. McCullough;Alpa V. Patel;E. Calle;V. Cokkinides;M. Thun
中科院分区：
文献类型：
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作者：
A. Chao;C. Connell;E. Jacobs;M. McCullough;Alpa V. Patel;E. Calle;V. Cokkinides;M. Thun
体育活动一直与结肠癌的低风险相关，但有关活动的数量，类型和时间的信息有限。身体活动与直肠癌之间的关系尚不清楚。我们在癌症预防研究II营养队列中研究了与结肠癌和直肠癌相关的娱乐性体力活动的特征，该队列包括70，403名男性和80，771名女性（中位年龄63岁）;从1992年至1993年至1999年8月的登记中确定了940例结肠癌和390例直肠癌。多变量校正率比（95%置信区间）与任何娱乐性体力活动相比，结肠癌为0.87（0.71-1.06），直肠癌为0.70（0.53-0.93）。结肠癌风险随着每周活动总小时数（无参考组趋势P = 0.007）和代谢当量小时数（趋势P = 0.006）的增加而显著降低。直肠癌的风险并没有随着每周体力活动时间的增加而明显降低。每周体力活动≥ 7小时与无体力活动的比率（95%置信区间）为0.72（0.52-0.98）。据1982年报道，过去的运动与结肠癌或直肠癌的风险无关。我们的结论是，在娱乐性体育活动上花费的时间增加与结肠癌的风险大幅降低有关，并且娱乐性体育活动与老年男性和女性的直肠癌风险降低有关。
Physical activity has consistently been associated with lower risk of colon cancer, but information is limited on the amount, type, and timing of activities. The relationship between physical activity and rectal cancer is unclear. We examined characteristics of recreational physical activity in relation to colon and rectal cancer in the Cancer Prevention Study II Nutrition Cohort of 70,403 men and 80,771 women (median age, 63 years); 940 colon and 390 rectal cancers were identified from enrollment in 1992 to 1993 through August 1999. The multivariate-adjusted rate ratios (95% confidence intervals) associated with any recreational physical activity compared with none were 0.87 (0.71-1.06) for colon cancer and 0.70 (0.53-0.93) for rectal cancer. Colon cancer risk decreased significantly with increasing total hours (P for trend without reference group = 0.007) and metabolic equivalent hours (P for trend = 0.006) per week of activities. No clear decrease in rectal cancer risk was seen with increasing hours per week of physical activity. Rate ratios (95% confidence intervals) were 0.72 (0.52-0.98) for /=7 hours per week of physical activity compared with none. Past exercise, as reported in 1982, was not associated with risk of either colon or rectal cancer. We conclude that increasing amounts of time spent at recreational physical activity are associated with substantially lower risk of colon cancer and that recreational physical activity is associated with lower risk of rectal cancer in older men and women.