Charge migration in dicationic electrophiles and its application to the synthesis of aza-polycyclic aromatic compounds.
Charge migration in dicationic electrophiles and its application to the synthesis of aza-polycyclic aromatic compounds.
复制标题
双亲电子试剂中的电荷迁移及其在氮杂多环芳香族化合物合成中的应用。
DOI：
10.1021/ol060125u
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发表时间：
2006
期刊：
影响因子：
5.2
通讯作者：
Klumpp,DouglasA
中科院分区：
文献类型：
--
作者：
Li,Ang;Kindelin,PatrickJ;Klumpp,DouglasA
研究了超强酸促进的双阳离子亲电试剂的反应，发现正电荷中心以可预测的方式迁移。使用同位素标记，发现在一个系统中，电荷迁移是通过连续的去质子化-再质子化步骤发生的。电荷迁移化学是氮杂多环芳香族化合物合成新途径的基础。
Superacid-promoted reactions of dicationic electrophiles have been studied, and the positive charge centers are found to migrate apart in a predictable manner. Using isotopic labeling the charge migration is found in one system to occur through successive deprotonation−reprotonation steps. The charge migration chemistry is the basis for new general synthetic route to aza-polycyclic aromatic compounds.