Antiepileptic medications in multiple sclerosis: adverse effects in a three-year follow-up study
Antiepileptic medications in multiple sclerosis: adverse effects in a three-year follow-up study
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DOI：
10.1007/s10072-004-0362-9
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发表时间：
2005-02-01
影响因子：
3.3
通讯作者：
Mancardi, GL
中科院分区：
文献类型：
--
作者：
Solaro, C;Brichetto, G;Mancardi, GL
神经性疼痛和阵发性症状在多发性硬化（MS）患者中很常见，尽管尚未进行双盲临床试验以支持抗癫痫药物（AED）在MS中的使用。本研究的目的是评估MS患者队列中AED使用频率和报告的不良事件。在数据库中记录了3年期间的AED处方依据、不良反应、治疗持续时间和停药原因。卡马西平（CBZ）处方36例，20例报告的不良反应，其中12模仿复发。加巴喷丁（GBP）在94例患者中使用，16例报告了不良反应，1例模拟复发。拉莫三嗪（LMT）处方22例，有4例报告的不良反应，没有模仿复发。本研究发现，与GBP或LMT相比，CBZ治疗患者的不良反应发生率显著较高，低剂量下的停药率较高，神经功能明显恶化。
Neuropathic pain and paroxysmal symptoms are common in multiple sclerosis (MS) patients, although no double-blind clinical trial has been conducted to support antiepileptic medications (AED) use in MS. The aim of the study was to evaluate the frequency of AED utilisation and reported adverse events, in a cohort of MS patients. For a period of 3 years the rationale for prescribing AED, adverse effects, treatment duration and reasons for discontinuation were recorded in a database. Carbamazepine (CBZ) was prescribed in 36 patients, with adverse effects reported in 20 cases, of which 12 mimicked a relapse. Gabapentin (GBP) was prescribed in 94 patients, with adverse effects reported in 16 cases and in one case mimicked a relapse. Lamotrigine (LMT) was prescribed in 22 patients, with adverse effects reported in 4 cases, none mimicking a relapse. The present study found a significantly higher incidence of adverse effects in patients treated with CBZ, with a high rate of discontinuation at low dosages and episodes of evident worsening of neurological functioning compared to GBP or LMT.