Candidemia in patients with head and neck cancer: mortality and a novel risk factor
Candidemia in patients with head and neck cancer: mortality and a novel risk factor
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头颈癌患者的念珠菌血症：死亡率和新的危险因素
DOI：
10.1007/s00520-022-07010-9
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发表时间：
2022
影响因子：
3.1
通讯作者：
Ando Mizuo
中科院分区：
文献类型：
--
作者：
Uraguchi Kensuke;Makino Takuma;Kariya Shin;Noda Youhei;Marunaka Hidenori;Doi Akira;Kozakura Kenichi;Takao Soshi;Ando Mizuo
目的念珠菌血症是由念珠菌属引起的一种血流感染。并且与高死亡率相关。然而，关于BSI在头颈癌（HNC）中的应用报道较少。我们旨在评估念珠菌血症对HNC患者的影响，并将其与菌血症进行比较。研究设计多中心回顾性研究。方法我们回顾性分析了2011年至2020年HNC中的83例BSI发作，并将其分为念珠菌血症和菌血症组。然后，我们比较了生存率和危险因素之间的groups.ResultsThe总体累积发病率（风险）的念珠菌血症BSI为12 83发作（14.5%）。菌血症和念珠菌血症组的1年死亡率分别为33.3%和58.3%（log-rankp= 0.041）。广谱抗生素（优势比[OR]：29.5; 95%置信区间[CI]，2.49-350），粘膜炎（OR 11.0; 95% CI，1.52-80.1），和恶性伤口（OR 79.5; 95% CI 1.33-4737）是显着的危险因素，念珠菌血症在HNC。据我们所知，恶性伤口以前没有报道为念珠菌血症的危险因素。对于念珠菌血症的早期诊断和治疗，应考虑危险因素，并尽早开始抗真菌治疗。
PurposeCandidemia is a bloodstream infection (BSI) by Candida spp. and is associated with high mortality. However, there have been few reports about BSI in head and neck cancer (HNC). We aimed to evaluate the impact of candidemia in patients with HNC and compared it with bacteremia.Study designA multicenter retrospective study.MethodsWe retrospectively analyzed 83 BSI episodes in HNC (2011 to 2020) and divided them into the candidemia and bacteremia groups. We then compared the survival rate and risk factors for candidemia between the groups.ResultsThe overall cumulative incidence (risk) of candidemia in BSI was 12 out of 83 episodes (14.5%). The 1-year mortality for the bacteremia and candidemia groups was 33.3% and 58.3%, respectively (log-rankp= 0.041). Broad-spectrum antibiotics (odds ratio [OR]: 29.5; 95% confidence interval [CI], 2.49–350), mucositis (OR 11.0; 95% CI, 1.52–80.1), and malignant wounds (OR 79.5; 95% CI 1.33–4737) were significant risk factors for candidemia in HNC.ConclusionsCandidemia causes high mortality in patients with HNC. To our knowledge, malignant wounds have not been previously reported as a risk factor for candidemia. For early diagnosis and treatment of candidemia, risk factors should be considered, and antifungal therapy started earlier.
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影响因子：
4.9
作者：
Ostrosky-Zeichner, Luis;Pappas, Peter G.;Sobel, Jack D.
通讯作者：
Sobel, Jack D.
影响因子：
4.9
作者：
Koehler, Philipp;Denis, Blandine;Cornely, Oliver A.
通讯作者：
Cornely, Oliver A.
住院肿瘤患者的恶性伤口：患病率、特征和相关因素
影响因子：
--
作者：
Flávia Firmino;Suzana Aparecida da Costa Ferreira;E. Franck;Wilka Medeiros Silva de Queiroz;Diana Villela Castro;P. Nogueira;V. Santos
通讯作者：
V. Santos
DOI：
10.1093/jac/dku414
发表时间：
2015-02
期刊：
The Journal of antimicrobial chemotherapy
影响因子：
--
作者：
Takesue Y;Ueda T;Mikamo H;Oda S;Takakura S;Kitagawa Y;Kohno S;ACTIONs Project
通讯作者：
ACTIONs Project
影响因子：
4.7
作者：
Maida, Vincent;Ennis, Marguerite;Trozzolo, Linda
通讯作者：
Trozzolo, Linda