The cyclic-di-GMP signaling pathway in the Lyme disease spirochete, Borrelia burgdorferi.
The cyclic-di-GMP signaling pathway in the Lyme disease spirochete, Borrelia burgdorferi.
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DOI：
10.3389/fcimb.2014.00056
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发表时间：
2014
影响因子：
5.7
通讯作者：
Motaleb MA
中科院分区：
文献类型：
--
作者：
Novak EA;Sultan SZ;Motaleb MA
在自然界中，莱姆病螺旋体伯氏疏螺旋体在硬蜱媒介和哺乳动物宿主的不相关环境之间循环。为了在主机之间的传输中存活，B。伯氏菌不仅要能发现环境的变化，还要能对这些变化作出迅速而适当的反应。这种专性寄生虫调节和适应其不断变化的环境的一种方式是通过循环二GMP（c-di-GMP）信号传导。c-di-GMP已显示在协调B的适应中起作用。burgdorferi到蜱虫环境。B。burgdorferi仅具有一组c-di-GMP-代谢基因（一种二鸟苷酸环化酶和两种不同的磷酸二酯酶）和一种被称为PlzA的c-di-GMP-结合PilZ-结构域蛋白。而在B.虽然近年来盗窃案激增，但问题仍然多于答案。阐明c-di-GMP信号传导对B的重要性。burgdorferi可能导致识别对B的存活至关重要的机制。在蜱阶段的地方性流行周期以及潜在的描绘的作用（如果有的话）c-di-GMP可能发挥的传播和毒性的B。本发明提供了在地方性流行病周期中分离莱姆病螺旋体的方法，从而能够开发用于预防和/或治疗莱姆病的有效药物。
In nature, the Lyme disease spirochete Borrelia burgdorferi cycles between the unrelated environments of the Ixodes tick vector and mammalian host. In order to survive transmission between hosts, B. burgdorferi must be able to not only detect changes in its environment, but also rapidly and appropriately respond to these changes. One manner in which this obligate parasite regulates and adapts to its changing environment is through cyclic-di-GMP (c-di-GMP) signaling. c-di-GMP has been shown to be instrumental in orchestrating the adaptation of B. burgdorferi to the tick environment. B. burgdorferi possesses only one set of c-di-GMP-metabolizing genes (one diguanylate cyclase and two distinct phosphodiesterases) and one c-di-GMP-binding PilZ-domain protein designated as PlzA. While studies in the realm of c-di-GMP signaling in B. burgdorferi have exploded in the last few years, there are still many more questions than answers. Elucidation of the importance of c-di-GMP signaling to B. burgdorferi may lead to the identification of mechanisms that are critical for the survival of B. burgdorferi in the tick phase of the enzootic cycle as well as potentially delineate a role (if any) c-di-GMP may play in the transmission and virulence of B. burgdorferi during the enzootic cycle, thereby enabling the development of effective drugs for the prevention and/or treatment of Lyme disease.
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