A physiologic model for recirculation water correction in CMRO2 assessment with 15O2 inhalation PET
A physiologic model for recirculation water correction in CMRO2 assessment with 15O2 inhalation PET
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DOI：
10.1038/jcbfm.2008.132
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发表时间：
2009-02-01
影响因子：
6.3
通讯作者：
Iida, Hidehiro
中科院分区：
文献类型：
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作者：
Kudomi, Nobuyuki;Hayashi, Takuya;Iida, Hidehiro
脑氧代谢率（CMRO 2）可以使用O-15（2）和正电子发射断层扫描定量评估。确定动脉输入功能对于从测量的全血中分离O-15（2）（RW）的代谢产物至关重要。提出了一个基于生理模型的预测RW的数学公式。本研究旨在验证该模型的适当性以及将该模型应用于广泛种属和生理条件的简化程序。该公式由四个参数组成，包括对应于全身氧化代谢（BMRO 2）的RW（k）的产生速率。实验对象为6只猴、3只猪、12只大鼠和231名临床病人，其中猴在不同的生理条件下进行研究。该公式重现了观察到的RW。在较小的动物中观察到较大的k值，而其他参数在物种之间没有差异。模拟显示CMRO 2仅对k敏感，但对其他不敏感，表明仅从单个血液样品中测定k的有效性。此外，k与BMRO 2相关，表明可以从BMRO 2确定k。本模型和简化程序可用于评估CMRO 2的条件和物种范围广泛。
Cerebral metabolic rate of oxygen (CMRO2) can be assessed quantitatively using O-15(2) and positron emission tomography. Determining the arterial input function is considered critical with regards to the separation of the metabolic product of O-15(2) (RW) from a measured whole blood. A mathematical formula based on physiologic model has been proposed to predict RW. This study was intended to verify the adequacy of that model and a simplified procedure applying that model for wide range of species and physiologic conditions. The formula consists of four parameters, including of a production rate of RW (k) corresponding to the total body oxidative metabolism (BMRO2). Experiments were performed on 6 monkeys, 3 pigs, 12 rats, and 231 clinical patients, among which the monkeys were studied at varied physiologic conditions. The formula reproduced the observed RW. Greater k values were observed in smaller animals, whereas other parameters did not differ amongst species. The simulation showed CMRO2 sensitive only to k, but not to others, suggesting that validity of determination of only k from a single blood sample. Also, k was correlated with BMRO2, suggesting that k can be determined from BMRO2. The present model and simplified procedure can be used to assess CMRO2 for a wide range of conditions and species.