Increased carotid artery intima-media thickness and impaired endothelial function in psoriasis
Increased carotid artery intima-media thickness and impaired endothelial function in psoriasis
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DOI：
10.1111/j.1468-3083.2008.02936.x
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发表时间：
2009-01-01
影响因子：
9.2
通讯作者：
Egilmez, E.
中科院分区：
文献类型：
--
作者：
Balci, D. D.;Balci, A.;Egilmez, E.
牛皮癣与动脉粥样硬化的风险增加有关。这项研究利用高分辨率超声对寻常型银屑病患者和健康对照组的颈动脉和臂动脉的亚临床动脉粥样硬化进行了比较。超声测量血流介导的肱动脉扩张(FMD)和硝酸甘油诱导的肱动脉扩张(NTD)以及颈总动脉(CCA)的内中膜厚度(IMT)。排除标准为糖尿病、高血压、肾功能衰竭、心脑血管病史。银屑病患者右侧、左侧及平均颈动脉内中膜厚度分别为0.607±0.144 mm与0.532±0.101 mm，0.611±0.157 mm与0.521+/-0.117 mm，0.609+/-0.146 mm与0.526±0.104 mm；P=0.006、P=0.003和P=0.003)。银屑病患者的平均FMD值和NTD值显著低于对照组(分别为13.36±6.39 mm比19.60±11.23 mm和21.08±8.38 mm比26.85±12.38 mm；P=0.002和P=0.013)。多元线性回归分析显示银屑病与IMT、FMD和NTD显著相关。此外，银屑病患者的FMD与病程有关，银屑病患者与健康对照组相比，颈总动脉内皮功能受损，颈总动脉IMT增厚。银屑病的存在是亚临床动脉粥样硬化的独立危险因素。
Psoriasis is associated with an increased risk of atherosclerosis. This study compared subclinical atherosclerosis of the carotid and brachial arteries in psoriasis vulgaris patients and healthy controls using high-resolution ultrasonography.We studied 43 psoriasis patients and 43 healthy controls matched for age and sex. Flow-mediated dilatation (FMD) and nitroglycerin-induced dilatation (NTD) of the brachial artery and intima-media thickness (IMT) of the common carotid arteries (CCA) were measured ultrasonographically. Diabetes mellitus, hypertension, renal failure, a history of cardiovascular or cerebrovascular disease were exclusion criteria. Subjects who were receiving lipid-lowering therapy, antihypertensive or anti-aggregant drugs, nitrates or long-term systemic steroids were also excluded.The mean IMT values of the right, left and averaged CCA of the psoriasis patients were significantly higher, compared with the controls (0.607 +/- 0.144 mm vs. 0.532 +/- 0.101 mm, 0.611 +/- 0.157 mm vs. 0.521 +/- 0.117 mm, and 0.609 +/- 0.146 mm vs. 0.526 +/- 0.104 mm; P = 0.006, P = 0.003 and P = 0.003, respectively). The mean FMD and NTD values of the psoriasis patients were significantly lower, compared with the controls (13.36 +/- 6.39 mm vs. 19.60 +/- 11.23 mm and 21.08 +/- 8.38 mm vs. 26.85 +/- 12.38 mm; P = 0.002 and P = 0.013, respectively). Multiple linear regression analysis revealed a significant association between psoriasis and the IMT, FMD and NTD. Moreover, the FMD in psoriasis patients was associated with disease duration.Psoriasis patients had impaired endothelial function and thicker IMT of the CCA, compared with the healthy control subjects. The presence of psoriasis was an independent risk factor for subclinical atherosclerosis.None declared.