Liver-fat accumulation and insulin resistance in obese women with previous gestational diabetes
Liver-fat accumulation and insulin resistance in obese women with previous gestational diabetes
复制标题
DOI：
10.1038/oby.2002.118
复制
发表时间：
2002-09-01
期刊：
影响因子：
--
通讯作者：
Ykik-Järvinen, H
中科院分区：
文献类型：
--
作者：
Tiikkainen, M;Tamminen, M;Ykik-Järvinen, H
TIIKKAINEN、MIRJA、MARJO TAMMINEN、ANNA-MAIJA HAKKINEN、ROBERT BERGHOLM、SATU VEHKAVAARA、JUHA HALAVAARA、KARI泰拉莫、AILA RISSANEN和HANNELE YKI-JARVINEN。有妊娠糖尿病史的肥胖妇女的肝脏脂肪蓄积和胰岛素抵抗。Obes Res. 2002; 10：859-867.目的：我们确定肝脏中的脂肪堆积是否与独立于肥胖的胰岛素抵抗特征相关。研究方法和程序：我们招募了27名肥胖的非糖尿病女性，其中肝脏脂肪（LFAT）含量通过质子光谱测定，腹腔内和皮下脂肪通过磁共振成像，胰岛素敏感性通过正葡萄糖胰岛素钳夹技术。这些女性根据其LFAT含量中位数（5%）分为低（3.2 +/- 0.3%）和高（9.8 +/- 1.5%）肝脏脂肪组。两组在年龄（低LFAT组36 +/-1岁，高LFAT组38 +/- 1岁）、体重指数（32.2 +/- 0.6 kg/m2，高LFAT组32.8 +/- 0.5 kg/m2）、腰臀比、腹内、皮下和总脂肪含量方面几乎相同。结果如下：与低LFAT的女性相比，高LI 7AT的女性具有胰岛素抵抗的特征，包括更高的空腹血清甘油三酯（1.93 +/-0.21 vs. 1.11 +/-0.09 mM，p < 0.01）和胰岛素（14 +/-3 vs. 10 +/-1 mU/L，p < 0.05）浓度。与低LFAT组相比，高LFAT组的24小时血压也较高，全身胰岛素敏感性较低。讨论内容：在患有妊娠糖尿病的肥胖妇女中，LFAT，而不是任何身体成分的测量，与胰岛素抵抗的特征相关。
TIIKKAINEN, MIRJA, MARJO TAMMINEN, ANNA-MAIJA HAKKINEN, ROBERT BERGHOLM, SATU VEHKAVAARA, JUHA HALAVAARA, KARI TERAMO, AILA RISSANEN, AND HANNELE YKI-JARVINEN. Liver-fat accumulation and insulin resistance in obese women with previous gestational diabetes. Obes Res. 2002; 10:859-867. Objective: We determined whether fat accumulation in the liver is associated with features of insulin resistance independent of obesity. Research Methods and Procedures: We recruited 27 obese nondiabetic women in whom liver fat (LFAT) content was determined by proton spectroscopy, intra-abdominal and subcutaneous fat by magnetic resonance imaging, and insulin sensitivity by the euglycemic insulin clamp technique. The women were divided based on their median LFAT content (5%) to groups with low (3.2 +/- 0.3%) and high (9.8 +/- 1.5%) liver fat. The groups were almost identical with respect to age (36 +/- 1 vs. 38 +/- 1 years in low vs. high-LFAT), body mass index (32.2 +/- 0.6 vs. 32.8 +/- 0.5 kg/m(2)), waist-to-hip ratio, intra-abdominal, subcutaneous, and total fat content. Results: Women with high LI7AT had features of insulin resistance including higher fasting serum triglyceride (1.93 +/- 0.21 vs. 1.11 +/- 0.09 mM, p < 0.01) and insulin (14 +/- 3 vs. 10 +/- 1 mU/L, p < 0.05) concentrations than women with low LFAT. The group with high LFAT also had higher 24-hour blood pressures, and lower whole-body insulin sensitivity compared with the low-LFAT group. Discussion: In obese women with previous gestational diabetes, LFAT, rather than any measure of body composition, is associated with features of insulin resistance.