Cognitive impairment in the euthymic phase of affective disorder
Cognitive impairment in the euthymic phase of affective disorder
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DOI：
10.1017/s0033291798006862
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发表时间：
1998-09-01
影响因子：
6.9
通讯作者：
Kessing, LV
中科院分区：
文献类型：
--
作者：
Kessing, LV
背景对单相和双相情感障碍的正常情感期认知研究的回顾揭示了不同的结果。该研究被设计为对照队列研究，丹麦精神病住院病例登记用于识别患者，丹麦民事登记用于识别对照。根据ICD-10，19至25年前因情感诊断而住院的患者，以及在访谈中符合原发性情感单极或双相障碍标准的患者，与年龄和性别匹配的对照组进行比较。在正常情绪期进行访谈和认知功能评估。共纳入118名单极患者、28名双相患者和58名对照者。分析调整了教育水平和亚临床抑郁和焦虑障碍的差异。反复发作的患者比单次发作的患者明显受损，比对照组受损更严重。此外，在患者中，既往发作次数似乎与认知结果相关。单极和双极患者的功能障碍的严重程度没有差异。门诊单相和双相情感障碍患者的认知功能障碍似乎与情感发作次数有关。
Background. A review of studies of cognition in the euthymic phase of unipolar and bipolar affective disorder reveals diverging results.Methods. The study was designed as a controlled cohort study, with the Danish psychiatric case register of admissions used to identify patients and the Danish civil register to identify controls. Patients who were hospitalized between 19 and 25 years ago with an affective diagnosis and who at interviews fulfilled criteria for a primary affective unipolar or bipolar disorder, according to ICD-10, were compared with age- and gender-matched controls. Interviews and assessment of the cognitive function were made in the euthymic phase of the disorder. In all, 118 unipolar patients, 28 bipolar patients and 58 controls were included. Analyses were adjusted for differences in the level of education and for subclinical depressive and anxiety symptoms.Results. Patients with recurrent episodes were significantly more impaired than patients with a single episode and more impaired than controls. Also, within patients the number of prior episodes seemed to be associated with cognitive outcome. There was no difference in the severity of the dysfunction between unipolar and bipolar patients.Conclusions. Cognitive impairment in out-patients with unipolar and bipolar disorder appears to be associated with the number of affective episodes.