Preparation, characterization, and blood compatibility of polylactide-based phospholipid polymer
Preparation, characterization, and blood compatibility of polylactide-based phospholipid polymer
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DOI：
10.1007/s10853-009-3870-4
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发表时间：
2009-12-01
影响因子：
4.5
通讯作者：
Wang, Bin
中科院分区：
文献类型：
--
作者：
Chen, Niancao;Chen, Yuanwei;Wang, Bin
从鸡蛋中提取卵磷脂，经水解得到1-α-甘油磷酸胆碱（GPC）。FT-IR和H-1-NMR分析表明GPC的制备是成功的。为改善聚乳酸（PLLA）在组织工程中的细胞/材料界面反应，采用凝胶渗透色谱（GPC）催化L-丙交酯开环聚合的方法合成了PLLA-PC。反应的产率强烈地依赖于反应时间。获得了80%以上的值，这远高于文献报道的值。在122 A ℃下反应48 h，得到分子量最大的共聚物.对PLLA-PC共聚物的性能和生物相容性进行了表征。根据X射线光电子能谱数据，检测到由于动态分子运动的表面重排。此外，由于共聚物中的亲水性磷酸胆碱基团，亲水性增加，纤维蛋白原吸附和血小板粘附性降低。
l-alpha-glycerophosphorylcholine (GPC) was obtained by hydrolysis of lecithin extracted from eggs. FT-IR and H-1-NMR analysis indicated a successful preparation of GPC. Polylactide-based phospholipid polymer (PLLA-PC) was synthesized by ring-opening polymerization of l-lactide in the presence of GPC to improve the cell/material interfacial reaction of PLLA for tissue engineering applications. The yield of the reaction strongly depended on the reaction time. Values above 80% were obtained which are much higher than those reported in literature. Copolymers with the largest molecular weights were obtained at 122 A degrees C for 48 h. The properties and biocompatibility of the PLLA-PC copolymers were characterized. Surface rearrangement was detected due to the dynamic molecular motion according to X-ray photoelectron spectroscopy data. Besides, increase in hydrophilicity and decreases in fibrinogen adsorption and platelet adhesion were observed due to the hydrophilic phosphorylcholine moieties in the copolymer.