Hippocampal agenesis in an individual who engaged in violent criminal behaviors after discontinuing carbamazepine and paroxetine treatment.
Hippocampal agenesis in an individual who engaged in violent criminal behaviors after discontinuing carbamazepine and paroxetine treatment.
复制标题
停止卡马西平和帕罗西汀治疗后从事暴力犯罪行为的个体海马发育不全。
DOI：
10.1111/j.1556-4029.2012.02248.x
复制
发表时间：
2013
影响因子：
1.6
通讯作者：
Yoshihisa Kawano.
中科院分区：
文献类型：
--
作者：
Hiroaki Hanada;Jotaro Akiyoshi;Masayuki Kanehisa;Yoshinobu Ishitobi;Jusen Tsuru;Yoshihiro Tanaka;Tsuyoshi Shimomura;Yoshihisa Kawano.
抗抑郁药停药综合症(ADS)是在抗抑郁药突然停药后发生的。一名23岁的男性，患有右侧海马区发育不全，从8岁起就表现出性犯罪(性欲亢进)，并从13岁开始成功地接受卡马西平治疗。由于辞去工作后出现不稳定的情绪，他需要增加帕罗西汀和卡马西平的剂量。他突然停药3天，犯罪行为再次出现。我们使用磁共振成像和功能磁共振成像(FMRI)检测了停药前后大脑结构和活动的变化。只有在停药后，穿着泳衣的女孩的形象才会增加丘脑的活动。丘脑活动的改变可能导致性欲亢进。我们的结论是，卡马西平和帕罗西汀治疗抑制了原发性性欲亢进，停药导致了性欲亢进。
Antidepressant discontinuation syndrome (ADS) occurs after abrupt discontinuation of an antidepressant medication. A 23‐year‐old man with right hippocampal agenesis demonstrated sexual crime (hypersexuality) since the age of eight and had been successfully treated with carbamazepine since the age of 13. He had required increased doses of paroxetine and carbamazepine owing to the development of an unstable affect after quitting his job. He abruptly stopped taking his medication for 3 days and his criminal behaviors re‐emerged. We examined changes in brain structure and activity before and after medication cessation, using MRI and functional MRI (fMRI). The image of a girl in a swimsuit increased activity in the thalamus only after medication discontinuation. The alteration in thalamic activity might induce hypersexuality. We conclude that a primary hypersexuality had been suppressed with carbamazepine and paroxetine treatment, and the discontinuation of the medication caused the hypersexuality.