SIRT1 Expression Is a Promising Prognostic Biomarker in Esophageal Squamous Cell Carcinoma: A Systematic Review and Meta-analysis.
SIRT1 Expression Is a Promising Prognostic Biomarker in Esophageal Squamous Cell Carcinoma: A Systematic Review and Meta-analysis.
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DOI：
10.21873/cdp.10086
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发表时间：
2022-03
期刊：
影响因子：
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通讯作者：
Ryota Otsuka;H. Sakata;Kentaro Murakami;M. Kano;S. Endo;Takeshi Toyozumi;Y. Matsumoto;H. Suito;Masahiko Takahashi;Nobufumi Sekino;S. Hirasawa;K. Kinoshita;Takuma Sasaki;H. Matsubara
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文献类型：
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作者：
Ryota Otsuka;H. Sakata;Kentaro Murakami;M. Kano;S. Endo;Takeshi Toyozumi;Y. Matsumoto;H. Suito;Masahiko Takahashi;Nobufumi Sekino;S. Hirasawa;K. Kinoshita;Takuma Sasaki;H. Matsubara
背景/目的一些文献评估了sirtuin 1（SIRT 1）在食管鳞状细胞癌（ESCC）中表达的预后意义。然而，这方面的证据不足。因此，我们进行了一项荟萃分析，以研究SIRT 1表达在ESCC中的预后和临床影响。材料与方法我们检索了PubMed、科克伦图书馆和Web of Science数据库中关于SIRT 1表达和ESCC患者临床病理特征的文章。进行了荟萃分析。结果共纳入4篇文献，429例患者。荟萃分析显示SIRT 1的高表达与高T分期之间存在显著相关性（比值比=2.39）。95%置信区间=1.12-5.13，p=0.02），TNM分期更晚期（比值比=2.35。95%置信区间=1.20-4.60，p=0.01）和较差的总生存期（风险比=1.90，95%置信区间=1.45-2.47，p<0.00001）。结论SIRT 1表达可能是食管鳞癌患者预后的一个有前景的生物标志物。
Background/Aim Several articles have assessed the prognostic significance of the expression of sirtuin 1 (SIRT1) in esophageal squamous cell carcinoma (ESCC). However, evidence in this field is insufficient. Thus, we conducted a meta-analysis to investigate the prognostic and clinical impact of SIRT1 expression in ESCC. Materials and Methods We searched the PubMed, Cochrane Library, and Web of Science databases for articles on the expression of SIRT1 and clinicopathological features in patients with ESCC. A meta-analysis was conducted. Results Four studies with 429 patients were included. The meta-analysis revealed a significant relationship between the high expression of SIRT1 and higher T-stage (odds ratio=2.39. 95% confidence interval=1.12-5.13, p=0.02), more advanced TNM stage (odds ratio=2.35. 95% confidence interval=1.20-4.60, p=0.01), and a poor overall survival (hazard ratio=1.90, 95% confidence interval=1.45-2.47, p<0.00001). Conclusion SIRT1 expression may be a promising prognostic biomarker for patients with ESCC.