Ebola Virus: Melatonin as a Readily Available Treatment Option
Ebola Virus: Melatonin as a Readily Available Treatment Option
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DOI：
10.1002/jmv.24130
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发表时间：
2015-04-01
影响因子：
12.7
通讯作者：
Rodriguez, Moses
中科院分区：
文献类型：
--
作者：
Anderson, George;Maes, Michael;Rodriguez, Moses
目前迫切需要一种可行的、廉价的、现成的治疗西非埃博拉病毒疫情的方法。在这里，有人提出，褪黑激素可能有显着的效用，在帮助管理这种爆发。优化自然杀伤（NK）细胞反应似乎对埃博拉病毒感染的生存至关重要。褪黑激素显着增加NK细胞的细胞毒性，表明在管理埃博拉病毒的功效。在挑战条件下，褪黑激素增加血红素加氧酶-1（HO-1），从而抑制埃博拉病毒复制。褪黑激素在感染性休克的情况下也具有保护作用，尽管感染性休克是细菌性的，但具有类似的涉及血管渗漏的终点表现。褪黑激素对出血的影响主要是通过减少促炎细胞因子介导的。通过优化适当的免疫反应，褪黑激素可能为埃博拉病毒感染的高风险人群提供保护，并对感染过程本身产生直接影响。虽然没有直接的数据涉及褪黑激素在埃博拉病毒的管理中的效用，收敛机构的数据表明其效用，这是在这篇文章中进行审查。医学病毒学杂志87：537-543，2015. (c)2015 Wiley Periodicals，Inc.
There is currently an urgent need for a viable, cheap, and readily available treatment for the Ebola virus outbreak in West Africa. Here, it is proposed that melatonin may have significant utility in helping the management of this outbreak. Optimizing natural killer (NK) cell responses seems crucial to surviving Ebola virus infection. Melatonin increases NK cell cytotoxicity significantly, suggesting efficacy in managing the Ebola virus. Under conditions of challenge, melatonin increases heme oxygenase-1 (HO-1), which inhibits Ebola virus replication. Melatonin also has protective effects in cases of septic shock, which, although bacterial, has similar end-point presentations involving blood vessel leakage. Melatonin's effects on haemorrhage are mediated primarily by a decrease in pro-inflammatory cytokines. By optimizing the appropriate immune response, melatonin is likely to afford protection to those at high risk of Ebola viral infection, as well as having direct impacts on the course of infection per se. Although no direct data pertain to the utility of melatonin in the management of the Ebola virus, convergent bodies of data suggest its utility, which is reviewed in this article. J. Med. Virol. 87:537-543, 2015. (c) 2015 Wiley Periodicals, Inc.