Progressive Resistance Training to Impact Physical Fitness and Body Weight in Pancreatic Cancer Patients A Randomized Controlled Trial
Progressive Resistance Training to Impact Physical Fitness and Body Weight in Pancreatic Cancer Patients A Randomized Controlled Trial
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DOI：
10.1097/mpa.0000000000001221
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发表时间：
2019-02-01
期刊：
影响因子：
2.9
通讯作者：
Steindorf, Karen
中科院分区：
文献类型：
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作者：
Wiskemann, Joachim;Clauss, Dorothea;Steindorf, Karen
目的维持或改善肌肉质量和肌力是胰腺癌(PC)患者的重要治疗目标，因为其存在较高的恶病质风险。因此，我们在随机对照试验中评估了对PC患者进行为期6个月的渐进式阻力训练(RT)的可行性和有效性。方法65例PC患者随机分为有监督进展式RT(RT1)、居家RT(RT2)和常规护理对照组(CON)。两个运动组均进行每周2次训练，为期6个月。在干预前后评估膝关节、肘部和髋部伸肌和屈肌的肌力以及心肺功能和体重。结果65例患者中，43例进入分析。服药依从率分别为64.1%(RT1)和78.4%(RT2)。与CON和RT2相比，RT1在肘屈伸肌力和最大工作负荷方面有显著改善(P<；0.05)。此外，与CON相比，膝关节伸肌在RT1上有显著改善(P<；0.05)。随着时间的推移，体重没有显示出显著的组间差异。结论渐进式RT在PC患者中是可行的，可改善肌力，对某些肌群效果显著。有监督的放疗似乎比基于家庭的放疗更有效。
Objectives Maintaining or improving muscle mass and muscle strength is an important treatment goal in pancreatic cancer (PC) patients because of high risk of cachexia. Therefore, we assessed feasibility and effectivity of a 6-month progressive resistance training (RT) in PC patients within a randomized controlled trial. Methods Sixty-five PC patients were randomly assigned to either supervised progressive RT (RT1), home-based RT (RT2), or usual care control group (CON). Both exercise groups performed training 2 times per week for 6 months. Muscle strength for knee, elbow, and hip extensors and flexors and cardiorespiratory fitness and body weight were assessed before and after the intervention period. Results Of 65 patients, 43 patients were analyzed. Adherence rates were 64.1% (RT1) and 78.4% (RT2) of the prescribed training sessions. RT1 showed significant improvements in elbow flexor/extensor muscle strength and in maximal work load versus CON and RT2 (P < 0.05). Further, knee extensors were significantly improved for RT1 versus CON (P < 0.05). Body weight revealed no significant group differences over time. Conclusions Progressive RT was feasible in PC patients and improved muscle strength with significant results for some muscle groups. Supervised RT seemed to be more effective than home-based RT.