Repeated access to sucrose augments dopamine turnover in the nucleus accumbens
Repeated access to sucrose augments dopamine turnover in the nucleus accumbens
复制标题
DOI：
10.1097/00001756-200212030-00010
复制
发表时间：
2002-12-03
期刊：
影响因子：
1.7
通讯作者：
Norgren, R
中科院分区：
文献类型：
--
作者：
Hajnal, A;Norgren, R
多巴胺在丘脑核中与动机行为有关，包括进食。正常的进食是有模式的，但人们对这些时间表如何影响这个神经系统知之甚少。我们假设，重复获得偏好的食物会增加多巴胺的清除。限制喂养时间表上的大鼠获得0.3 M蔗糖或水，2小时后进食。将大鼠保持这种方案7天，在最后一天进行微透析。在饮食期间，多巴胺营业额在脑桥核是更高的，之前由蔗糖比水。这一发现表明，在某些饮食条件下，神经适应发生在对进食的反应中，这些变化反过来可能会影响未来的饮食。
Dopamine in the nucleus accumbens has been implicated in motivated behavior, including feeding. Normal feeding occurs in patterns, but little is known about how these schedules influence this neural system. We hypothesized that repeated access to preferred foods would augment dopamine clearance. Rats on a restricted feeding schedule had access to 0.3 M sucrose or water followed 2 h later by chow. The rats were kept on this regimen for 7 days, with microdialysis performed on the last day. During the chow period, dopamine turnover in the nucleus accumbens was higher when preceded by sucrose than by water. This finding suggests that, under some dietary conditions, neuroadaptation occurs in response to feeding and these changes may, in turn, influence future meals.