CHEMOPREVENTIVE EFFECT OF TURMERIC AGAINST STOMACH AND SKIN TUMORS INDUCED BY CHEMICAL CARCINOGENS IN SWISS MICE
CHEMOPREVENTIVE EFFECT OF TURMERIC AGAINST STOMACH AND SKIN TUMORS INDUCED BY CHEMICAL CARCINOGENS IN SWISS MICE
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DOI：
10.1080/01635589209514174
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发表时间：
1992-01-01
影响因子：
2.9
通讯作者：
BHIDE, SV
中科院分区：
文献类型：
--
作者：
AZUINE, MA;BHIDE, SV
研究了饲料中姜黄对苯并[a]芘(BP)诱导的前胃肿瘤和7，12-二甲基苯并[a]菲(DMBA)诱导的雌性瑞士小鼠皮肤肿瘤的抑制作用。为进一步阐明姜黄的抗肿瘤作用机制，研究了姜黄对雌性瑞士小鼠肝脏细胞色素b5、细胞色素P-450、谷胱甘肽和谷胱甘肽S转移酶活性的影响。饲料中的姜黄酸(2%或5%)对BP诱发的前胃肿瘤有明显的抑制作用，且呈剂量和时间依赖性。2%的姜黄粉显著抑制DMBA诱发的小鼠皮肤肿瘤。连续7天饲喂5%的姜黄粉，肝脏细胞色素b5和细胞色素P-450水平下降38%。肝脏中谷胱甘肽含量提高12%，谷胱甘肽S转移酶活性提高32%。我们的结果证明姜黄对BP诱导的小鼠前胃和DMBA诱导的小鼠皮肤肿瘤具有保护作用。
The anticarcinogenic effect of dietary turmeric on benzo[a]pyrene-(BP) induced fore-stomach neoplasia and 7,12-dimethylbenz[a]anthracene (DMBA)-induced skin tumorigenesis in female Swiss mice was evaluated. To further elucidate the mechanism of antineoplastic action of turmeric, its effect on the hepatic cytochrome b5, cytochrome P-450, glutathione, and glutathione S-transferase activities was studied in female Swiss mice. Turmeric (2% or 5%) in the diet significantly inhibited the BP-induced forestomach tumors, and this response was dose and time dependent. The 2% turmeric diet significantly suppressed DMBA-induced skin tumors in mice. The 5% turmeric diet for seven consecutive days resulted in a 38% decrease in the hepatic cytochrome b5 and cytochrome P-450 levels. Glutathione content was increased by 12%, and the glutathione S-transferase activity was enhanced by 32% in the liver. Our results document a protective effect of turmeric on BP-induced forestomach and DMBA-induced skin tumors in mice.