Localization of Glycine Neurotransmitter Transporter (GLYT2) Reveals Correlation with the Distribution of Glycine Receptor
Localization of Glycine Neurotransmitter Transporter (GLYT2) Reveals Correlation with the Distribution of Glycine Receptor
复制标题
甘氨酸神经递质转运蛋白 (GLYT2) 的定位揭示了与甘氨酸受体分布的相关性
作者：
F. Jursky;N. Nelson
Abstract: We studied by immunocytochemical localization, the glycine neurotransmitter transporter (GLYT2) in mouse brain, using polyclonal antibodies raised against recombinant N‐terminus and loop fusion proteins. Western analysis and immunocytochemistry of mouse brain frozen sections revealed caudal‐rostral gradient of GLYT2 distribution with massive accumulation in the spinal cord, brainstem, and less in the cerebellum. Immunoreactivity was detected in processes with varicosities but not cell bodies. A correlation was observed between the pattern we obtained and previously reported strychnine binding studies. The results indicate that GLYT2 is involved in the termination of glycine neurotransmission accompanying the glycine receptor at the classic inhibitory system in the hindbrain.
DOI：
10.1073/pnas.89.15.7189
发表时间：
1992-08-01
影响因子：
11.1
作者：
GUASTELLA, J;BRECHA, N;DAVIDSON, N
通讯作者：
DAVIDSON, N