Sensory gating deficits during the mid-latency phase of information processing in medicated schizophrenia patients
Sensory gating deficits during the mid-latency phase of information processing in medicated schizophrenia patients
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DOI：
10.1016/j.psychres.2004.01.007
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发表时间：
2004-05-30
影响因子：
11.3
通讯作者：
Bell, M
中科院分区：
文献类型：
--
作者：
Boutros, NN;Korzyukov, O;Bell, M
在信息处理的前注意阶段的感觉门控已被广泛研究。在信息处理的后续阶段发生的感觉门控过程还没有得到充分的研究。P50感觉门控和精神分裂症症状之间的关系仍不明确，N100和P200门控的临床相关性尚待研究。来自中潜伏期听觉诱发反应在注意前（P50）和注意（N100，P200）阶段的信息处理的感觉门控指数收集的精神分裂症患者谁是稳定的，主要是治疗非典型抗精神病药物（n = 23）和年龄和性别匹配的健康对照组（n = 23）。精神分裂症患者在信息处理的中潜伏期范围内有明显的习惯化或感觉门控困难。此外，我们发现P50衍生的感觉门控指数和更注意相关的P300诱发反应的振幅或潜伏期之间没有相关性。许多N100和P200门控测量与P300变量相关。最后，我们发现感觉门控指数和精神分裂症症状群之间没有相关性。这些结果表明，感觉门控是一个普遍的异常精神分裂症患者，并不限于前注意阶段的信息处理。此外，数据表明，N100和P200门控指数可能会影响后续的信息处理。(C)2004爱思唯尔爱尔兰有限公司保留所有权利。
Sensory gating during preattentive phases of information processing has been extensively examined. Sensory gating processes that occur during subsequent phases of information processing have not been fully examined. The relationship between P50 sensory gating and schizophrenia symptoms remains underspecified and the clinical correlates of N100 and P200 gating are yet to be examined. Sensory gating indices derived from the mid-latency auditory evoked responses during preattentive (P50) and attentive (N100, P200) phases of information processing were collected from schizophrenia patients who were stable and mainly being treated with atypical antipsychotic medications (n = 23) and age- and gender-matched healthy control subjects (n = 23). Schizophrenia patients had demonstrable habituation or sensory gating difficulties throughout the mid-latency range of information processing. Moreover, we found no correlations between P50-derived sensory gating indices and the amplitude or latency of the more attention-related P300 evoked response. A number of N100 and P200 gating measures correlated with P300 variables. Finally, we found no correlations between sensory gating indices and schizophrenia symptoms clusters. These results suggest that sensory gating is a pervasive abnormality in schizophrenia patients that is not limited to the preattentive phase of information processing. Furthermore, the data suggest that N100 and P200 gating indices may influence subsequent information processing. (C) 2004 Elsevier Ireland Ltd. All rights reserved.