Variable serum immunoglobulin G immune response to genetically distinct Eikenella corrodens strains coexisting in the human oral cavity.
Variable serum immunoglobulin G immune response to genetically distinct Eikenella corrodens strains coexisting in the human oral cavity.
复制标题
对人类口腔中共存的遗传上不同的腐蚀艾肯氏菌菌株的可变血清免疫球蛋白 G 免疫反应。
DOI：
10.1111/j.1399-302x.1998.tb00727.x
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发表时间：
1998
影响因子：
--
通讯作者：
Ashimoto,A
中科院分区：
文献类型：
--
作者：
Chen,C;Ashimoto,A
本研究采用酶联免疫吸附试验(EL ISA)检测了不同遗传特征的自体致密艾氏球虫血清免疫球蛋白G(IgG)水平。受试者20例，其中成人牙周炎患者10例，青少年牙周炎患者5例，牙周健康者5例。每个受试者都有2-8个基因上截然不同的人。腐蚀致密菌株。血清免疫球蛋白水平降至自体E。7例成人牙周炎患者、4例青少年牙周炎患者和1例牙周健康受试者的个体内腐蚀密度有显著差异。在疾病受试者中，血清免疫球蛋白水平与自体菌株和参考菌株ATCC 23834或FDC373之间的相关性很差。4名成人牙周炎患者和2名青少年牙周炎患者的血清免疫球蛋白水平对自体牙周炎患者有显著影响。与参考菌株相比，这六名受试者中有两人的血清免疫球蛋白水平较低，如果只使用参考菌株进行酶联免疫吸附试验，则会被归类为低免疫反应者。这项研究表明了使用自体移植的重要性。在评估血清对该生物体的免疫反应中的腐蚀性菌株。
This study examined the variable serum immunoglobulin G (IgG) levels to genetically distinct autologousEikenella corrodensstrains by enzyme‐linked immunosorbent assay (ELISA). Twenty subjects, including 10 adult periodontitis patients, 5 juvenile periodontitis patients and 5 periodontally healthy subjects were examined. Each subject was colonized by 2–8 genetically distinctE. corrodensstrains. The serum IgG levels to autologousE. corrodenswithin individuals were significantly different in 7 adult periodontitis patients, 4 juvenile periodontitis patients and a periodontally healthy subject. Poor correlation was found in diseased subjects between serum IgG levels to autologous strains and to reference strains ATCC 23834 or FDC 373. Four adult periodontitis patients and two juvenile periodontitis patients exhibited significant serum IgG levels to autologousE. corrodensstrains (two standard deviations above the mean for periodontally healthy subjects); two of these six diseased subjects exhibited low serum IgG levels to reference strains and would have been classified as low immune responders if only reference strains had been used in ELISA. This study showed the importance of using autologousE. corrodensstrains in the assessment of serum IgG immune responses to this organism.