N-MYC AMPLIFICATION CAUSES DOWN-MODULATION OF MHC CLASS-I ANTIGEN EXPRESSION IN NEUROBLASTOMA
N-MYC AMPLIFICATION CAUSES DOWN-MODULATION OF MHC CLASS-I ANTIGEN EXPRESSION IN NEUROBLASTOMA
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DOI：
10.1016/0092-8674(86)90509-x
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发表时间：
1986-12-05
期刊：
影响因子：
64.5
通讯作者：
WEINBERG, RA
中科院分区：
文献类型：
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作者：
BERNARDS, R;DESSAIN, SK;WEINBERG, RA
N-myc基因扩增与人神经母细胞瘤转移能力增加相关我们在这里表明，N-myc基因在大鼠神经母细胞瘤细胞系基因转移后的过度表达导致下调I类组织相容性抗原的表达，并增加这些细胞的体内生长速度和转移能力。干扰素治疗可逆转N-myc介导的MHC I类抗原表达下调，而不影响N-myc mRNA的稳态水平。当N-myc基因在大鼠成纤维细胞中表达时，没有发现对MHC I类抗原表达的影响，表明N-myc基因扩增引起的一些影响是细胞类型特异性的。
Amplification of the N-myc gene is correlated with increased metastatic ability of human neuroblastomas. We show here that overexpression of the N-myc gene in a rat neuroblastoma cell line following gene transfer causes down-modulation of class I histocompatibility antigen expression and increases in the in vivo growth rate and metastatic ability of these cells. N-myc-mediated down-modulation of MHC class I antigen expression could be reversed by treatment with interferon without affecting the steady state level of N-myc mRNA. No effect on MHC class I antigen expression was found when the N-myc gene was expressed in rat fibroblasts, indicating that some of the effects caused by N-myc gene amplification are cell-type-specific.