Targeting diffuse midline gliomas: The promise of focused ultrasound-mediated blood-brain barrier opening.
Targeting diffuse midline gliomas: The promise of focused ultrasound-mediated blood-brain barrier opening.
复制标题
DOI：
10.1016/j.jconrel.2023.11.037
复制
发表时间：
2023-11
期刊：
影响因子：
--
通讯作者：
Payton J. Martinez;Adam L. Green;Mark Borden
中科院分区：
文献类型：
--
作者：
Payton J. Martinez;Adam L. Green;Mark Borden
Diffuse midline gliomas (DMGs), including diffuse intrinsic pontine glioma, have among the highest mortality rates of all childhood cancers, despite recent advancements in cancer therapeutics. This is partly because, unlike some CNS tumors, the blood-brain barrier (BBB) of DMG tumor vessels remains intact. The BBB prevents the permeation of many molecular therapies into the brain parenchyma, where the cancer cells reside. Focused ultrasound (FUS) with microbubbles has recently emerged as an innovative and exciting technology that non-invasively permeabilizes the BBB in a small focal region with millimeter precision. In this review, current treatment methods and biological barriers to treating DMGs are discussed. State-of-the-art FUS-mediated BBB opening is then examined, with a focus on the effects of various ultrasound parameters and the treatment of DMGs.
