Phenazine-1-carboxylic acid, a secondary metabolite of Pseudomonas aeruginosa, alters expression of immunomodulatory proteins by human airway epithelial cells
Phenazine-1-carboxylic acid, a secondary metabolite of Pseudomonas aeruginosa, alters expression of immunomodulatory proteins by human airway epithelial cells
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DOI：
10.1152/ajplung.00086.2003
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发表时间：
2003-09-01
影响因子：
4.9
通讯作者：
Britigan, BE
中科院分区：
文献类型：
--
作者：
Denning, GM;Iyer, SS;Britigan, BE
铜绿假单胞菌是一种革兰氏阴性细菌，可在易感患者人群中引起急性和慢性肺部疾病。铜绿假单胞菌分泌大量蛋白质和次生代谢物，其中许多具有可能参与疾病发病机制的生物学效应。一种未知的小分子量因子在体外和体内均可增加IL-8的释放。为了确定这个因素，我们进行了
Pseudomonas aeruginosa is a gram-negative bacterium that causes both acute and chronic lung disease in susceptible patient populations. P. aeruginosa secretes numerous proteins and secondary metabolites, many of which have biological effects that likely contribute to disease pathogenesis. An unidentified small-molecular-weight factor was previously reported to increase IL-8 release both in vitro and in vivo. To identify this factor, we subjected the