Diabetic Retinopathy: Animal Models, Therapies, and Perspectives.
Diabetic Retinopathy: Animal Models, Therapies, and Perspectives.
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DOI：
10.1155/2016/3789217
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发表时间：
2016
影响因子：
4.3
通讯作者：
McGinnis JF
中科院分区：
文献类型：
--
作者：
Cai X;McGinnis JF
糖尿病视网膜病变（DR）是糖尿病的主要并发症之一。尽管已经做出了巨大的努力来揭示DR的病理机制，但DR的确切原因在很大程度上仍然未知。由于DR病因的多因素参与，目前尚无有效的治疗DR的方法。本文就DR的病理、常用的动物模型和新的治疗方法作一综述。讨论了DR治疗的前景和未来发展方向。
Diabetic retinopathy (DR) is one of the major complications of diabetes. Although great efforts have been made to uncover the mechanisms underlying the pathology of DR, the exact causes of DR remain largely unknown. Because of multifactor involvement in DR etiology, currently no effective therapeutic treatments for DR are available. In this paper, we review the pathology of DR, commonly used animal models, and novel therapeutic approaches. Perspectives and future directions for DR treatment are discussed.