IL-32: A Novel Pluripotent Inflammatory Interleukin, towards Gastric Inflammation, Gastric Cancer, and Chronic Rhino Sinusitis.
IL-32: A Novel Pluripotent Inflammatory Interleukin, towards Gastric Inflammation, Gastric Cancer, and Chronic Rhino Sinusitis.
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DOI：
10.1155/2016/8413768
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发表时间：
2016
影响因子：
4.6
通讯作者：
Sheikh N
中科院分区：
文献类型：
--
作者：
Khawar MB;Abbasi MH;Sheikh N
大量的非结构蛋白因其在许多生物现象中的关键作用和参与而被研究。白细胞介素-32（IL-32）是一种新的细胞因子，在除啮齿类动物外的大多数哺乳动物中均存在。IL-32基因在人染色体16 p13.3上鉴定。该基因有8个外显子和9个剪接变体，即IL-32α、IL-32β、IL-32γ、IL-32δ、IL-32ε、IL-32 β、IL-32 η、IL-32θ和IL-32 s。发现其诱导多种炎性细胞因子（包括TNF-α、IL-6和IL-1β）以及巨噬细胞炎性蛋白-2（MIP-2）的表达，并且先前已报道其参与许多炎性疾病的发病机制和进展，即炎性肠病（IBD）、胃炎症和癌症、类风湿性关节炎和慢性阻塞性肺病（COPD）。在当前的综述中，我们强调了IL-32在胃癌、胃炎症和慢性鼻窦炎中的作用。我们还试图探索各种可能诱导这种特殊细胞因子表达的机制以及IL-32在上述问题的介导和进展过程中所采用的各种作用机制。
A vast variety of nonstructural proteins have been studied for their key roles and involvement in a number of biological phenomenona. Interleukin-32 is a novel cytokine whose presence has been confirmed in most of the mammals except rodents. The IL-32 gene was identified on human chromosome 16 p13.3. The gene has eight exons and nine splice variants, namely, IL-32α, IL-32β, IL-32γ, IL-32δ, IL-32ε, IL-32ζ, IL-32η, IL-32θ, and IL-32s. It was found to induce the expression of various inflammatory cytokines including TNF-α, IL-6, and IL-1β as well as macrophage inflammatory protein-2 (MIP-2) and has been reported previously to be involved in the pathogenesis and progression of a number of inflammatory disorders, namely, inflammatory bowel disease (IBD), gastric inflammation and cancer, rheumatoid arthritis, and chronic obstructive pulmonary disease (COPD). In the current review, we have highlighted the involvement of IL-32 in gastric cancer, gastric inflammation, and chronic rhinosinusitis. We have also tried to explore various mechanisms suspected to induce the expression of this extraordinary cytokine as well as various mechanisms of action employed by IL-32 during the mediation and progression of the above said problems.