Is there a further acceleration in the age at onset of menarche? A cross-sectional study in 1840 school children focusing on age and bodyweight at the onset of menarche
Is there a further acceleration in the age at onset of menarche? A cross-sectional study in 1840 school children focusing on age and bodyweight at the onset of menarche
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DOI：
10.1530/eje-08-0594
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发表时间：
2009-01-01
影响因子：
5.8
通讯作者：
Krude, H.
中科院分区：
文献类型：
--
作者：
Bau, A. M.;Ernert, A.;Krude, H.
目的：30多年前Frisch和Revelle提出了一个初潮起始的体重阈值。基于这一假设，月经初潮的年龄进一步加速，可以预期在儿童obesity.Design的时间：一个横断面研究的1840名健康的女学生（柏林学校儿童队列，BSCOC）的年龄组10-15岁，在2006- 2007年进行。进行双因素和多因素分析来分析初潮年龄和体重状况之间的关系。局部加权回归分析身高，体重，体重指数（BMI）-SDS和年龄分层月经初潮status.Results：936（50.99%）的女孩已经经历了初潮的中位数年龄为12.8岁之间的关系。这些女孩中有236人最近达到了月经初潮。肥胖/超重女孩达到月经初潮的时间（12.5年）明显早于正常体重女孩（12.9年）和体重不足女孩（13.7年）。无论年龄（平均51.1 kg，S.D，8.1）和身高，所有女孩在月经初潮时的平均总体重相似。BMI-SDS仍然是初潮发生的唯一显着因素内的多元回归模型初潮早期（OR 2.1，95%置信区间1.3-3.3，P=0.002）。结论：初潮发生时的年龄并没有加速，即使在儿童人群肥胖患病率超过10%。然而，BMI-SDS与初潮年龄呈负相关。
Objective: More than 30 years ago 1 Frisch and Revelle proposed a body weight threshold for the onset of menarche. Based on this hypothesis, a further acceleration of age at menarche can be expected in times of childhood obesity.Design: A cross-sectional study of 1840 healthy school girls (Berlin school children's cohort, BSCOC) within the age groups 10-15 years was conducted in 2006-2007.Methods: Median age of menarche was calculated by Kaplan-Meier survival analysis. Bi- and multivariate analyses were performed to analyze the associations between menarche age and weight status. A locally weighted regression was used to analyze the relationship respectively between height, weight, and body mass index (BMI)-SDS and age stratified by menarche status.Results: Nine hundred and thirty six (50.99%) girls had already experienced menarche at a median age of 12.8 years. Two hundred and thirty six of these girls reached their menarche recently. Obese/overweight girls reached menarche significantly earlier (12.5 years), than normal weight (12.9 years), and underweight girls (13.7 years). The mean total body weight was similar in all girls at menarche irrespective of age (mean 51.1 kg,S.D, 8.1)and height. BMI-SDS remained the only significant factor for onset of menarche within a multiple regression model for early menarche (OR 2.1, 95% confidence interval 1.3-3.3, P=0.002).Conclusions: Age at onset of menarche did not accelerate even in a childhood population with more than 10% obesity prevalence. Nevertheless, a negative correlation of BMI-SDS with age at onset of menarche exists.