Autonomous Chemical Oscillator Circuit Based on Bidirectional Chemical‐Microfluidic Coupling
Autonomous Chemical Oscillator Circuit Based on Bidirectional Chemical‐Microfluidic Coupling
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DOI：
10.1002/admt.201600005
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发表时间：
2016-04
影响因子：
6.8
通讯作者：
G. Paschew;J. Schreiter;A. Voigt;Cesare Pini;J. P. Chávez;Merle Allerdißen;U. Marschner;S. Siegmund;R. Schüffny;F. Jülicher;A. Richter
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作者：
G. Paschew;J. Schreiter;A. Voigt;Cesare Pini;J. P. Chávez;Merle Allerdißen;U. Marschner;S. Siegmund;R. Schüffny;F. Jülicher;A. Richter
DOI（文件名称）：10.1002/admt.201600005 Mosadegh等人[ 3 ]开发的机械微流控振荡器是基于两个场效应型阀和两个用作顺应性的膜的弛张振荡器（类似于电子学中的非稳态多谐振荡器）。振荡器已被用于控制从属流体回路，[ 3 ]分析内皮细胞伸长，[ 5 ]并将时间模式化的化学浓度分布传递给活细胞。[ 4 ]研究还表明，单个芯片上的四个周期在0.4到2 h之间的独立振荡器可以并行操作，纯粹由重力驱动。[ 5 ] Xia等人[6，7]提出了一种不同的机械微流体振荡器方法，该方法基于具有单个过冲弹性膜片的简单设置。该装置产生周期约为10 ms的快速稳定振荡，频率可调性约为30%。虽然在这个范围内的频率是理想的快速流动混合，他们太快相比，许多化学或生物过程。所讨论的两种微流控振荡器都可用于输送试剂，但它们本身对化学浓度不敏感。自主振荡器是电子学和生物学中信号处理系统的关键部件。[1，2]将化学或生物系统与微流体的机械领域相结合的振荡器的发展可以激发流体及其成分的“智能”处理的新概念。在技术上，与电子振荡器相比，化学振荡器的实现具有挑战性。最近，微流控振荡器的结构已经被证明。[ 3-7 ]
DOI: 10.1002/admt.201600005 The mechanical microfl uidic oscillators developed by Mosadegh et al. [ 3 ] are relaxation oscillators (akin to astable multivibrators in electronics) based on two fi eld-effect-type valves and two membranes acting as compliances. The oscillators have been used to control subordinate fl uid circuits, [ 3 ] to analyze endothelial cell elongation, [ 5 ] and to deliver temporally patterned chemical concentration profi les to living cells. [ 4 ] It was also shown that four independent oscillators on a single chip with periods between 0.4 and 2 h could be operated in parallel, purely driven by gravity. [ 5 ] A different approach for a mechanical microfl uidic oscillator based on a simple setup with a single overshooting elastic diaphragm was shown by Xia et al. [ 6,7 ] The device produces fast stable oscillations with a period of about 10 ms with a limited frequency tunability of about 30%. Though frequencies in this range are ideal for rapid fl ow mixing, they are much too fast compared to many chemical or biological processes. Both microfl uidic oscillators discussed can be used to transport reagents, but they are not themselves responsive to chemical concentrations. Autonomous oscillators are a key component of signal processing systems in electronics and biology. [ 1,2 ] The development of oscillators that couple chemical or biological systems with the mechanical domain of microfl uidics could stimulate novel concepts for the “smart” handling of fl uids and their ingredients. In technology, the realization of chemical oscillators is challenging, in contrast to electronic oscillators. Recently, the construction of microfl uidic oscillators has been demonstrated. [ 3–7 ]