Serum uric acid level is associated with the incidence of heterotopic ossification following elbow trauma surgery
Serum uric acid level is associated with the incidence of heterotopic ossification following elbow trauma surgery
复制标题
血清尿酸水平与肘部创伤手术后异位骨化的发生率相关
DOI：
10.1016/j.jse.2020.01.071
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发表时间：
2020
影响因子：
3
通讯作者：
Deting Xue
中科院分区：
文献类型：
--
作者：
Jinwu Bai;Zhihui Kuang;Yimin Chen;Kai Hang;Jianxiang Xu;Deting Xue
背景：异位骨化(HO)是肘部创伤术后常见的并发症。尿酸是嘌呤代谢的最终产物，具有多种生理和致病作用。然而，HO和尿酸之间的关系还没有被探索。本研究旨在探讨HO与血尿酸(SUA)的关系。材料和方法：回顾分析2013年1月至2018年12月在本院接受肘部创伤手术的155例患者的资料。根据纳入标准纳入100例患者。按有无HO分为两组，组间比较采用独立样本t检验。结果：HO组血尿酸水平显著高于非HO组(362.0±87.4Mol/L vs 318.3±87.0Mol/μL，P<；0.05)。以优登指数最大值为标准，317.5μ/L为预测肘关节HO的最佳界值，其敏感度为68.75%(95%可信区间，54.67%~80.05%)，特异度为55.77%(95%可信区间，42.34%~68.40%)。以317.5μ/L作为预测肘关节HO发生发展的尿酸阈值，具有较高的敏感性和特异性。
Background: Heterotopic ossification (HO) is a common complication after surgery for elbow trauma. Uric acid is the end product of purine metabolism and has several physiological and pathogenic roles. However, the relationship between HO and uric acid has not been explored. This retrospective study aimed to assess the relationship between HO and serum uric acid (SUA)..Material and methods: We retrospectively reviewed data from 155 patients undergoing elbow trauma surgery in our hospital between January 2013 and December 2018. One hundred patients were included according to the inclusion criteria. They were divided into 2 groups according to the presence or absence of HO, and the SUA level was compared between groups using the independent samples t test. The optimal prognostic cutoff value was obtained using the maximum value of the Youden index..Results: The SUA level was significantly higher in the HO group than in the non-HO group (362.0 ± 87.4 μmol/L vs. 318.3 ± 87.0 μmol/L; P < .05). Using the maximum value of Youden index, 317.5 μmol/L was determined to be the optimal SUA cutoff value for the prediction of HO, with a sensitivity of 68.75% (95% confidence interval [CI], 54.67%-80.05%) and specificity of 55.77% (95% CI, 42.34%-68.40%)..Conclusions: Our study was the first to find that the high SUA level is a risk factor for HO of the elbow joint after trauma. Moreover, 317.5 μmol/L is the SUA threshold predicting the occurrence and development of HO of the elbow, with high sensitivity and specificity.