Microdomains for neuron-glia interaction:: parallel fiber signaling to Bergmann glial cells
Microdomains for neuron-glia interaction:: parallel fiber signaling to Bergmann glial cells
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DOI：
10.1038/5692
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发表时间：
1999-02-01
影响因子：
25
通讯作者：
Kettenmann, H
中科院分区：
文献类型：
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作者：
Grosche, J;Matyash, V;Kettenmann, H
星形胶质细胞被认为是一种网状细胞网络，钙信号可以通过它轻松传播。在Bergmann神经胶质，小脑的星形胶质细胞，我们确定了亚细胞区室称为“胶质细胞微域”。这些元件具有由薄膜片组成的复杂表面，包含很少的线粒体并包裹在突触周围。为了测试神经元与这些结构的相互作用，我们电刺激平行纤维。这种刺激增加了Bergmann神经胶质细胞过程中的小隔室中的细胞内钙浓度（[Ca2+]（i）），其大小与神经胶质微区相似。因此，伯格曼神经胶质细胞可能由数百个独立的隔室组成，这些隔室能够与它们所包裹的特定突触组进行自主相互作用。
Astrocytes are considered a reticulate network of cells, through which calcium signals can spread easily. In Bergmann glia, astrocytic cells of the cerebellum, we identified subcellular compartments termed 'glial microdomains'. These elements have a complex surface consisting of thin membrane sheets, contain few mitochondria and wrap around synapses. To test for neuronal interaction with these structures, we electrically stimulated parallel fibers. This stimulation increased intracellular calcium concentration ([Ca2+](i)) in small compartments within Bergmann glial cell processes similar in size to glial microdomains. Thus, a Bergmann glial cell may consist of hundreds of independent compartments capable of autonomous interactions with the particular group of synapses that they ensheath.