Biological effects of curcumin and its role in cancer chemoprevention and therapy
Biological effects of curcumin and its role in cancer chemoprevention and therapy
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DOI：
10.2174/187152006776930918
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发表时间：
2006-05-01
影响因子：
2.8
通讯作者：
Khar, Ashok
中科院分区：
文献类型：
--
作者：
Singh, Sarvjeet;Khar, Ashok
姜黄素是姜黄根茎中的一种天然成分，已成为最有效的化学预防剂和抗癌剂之一。其生物学作用范围从抗氧化、抗炎到抑制血管生成，并且还显示出具有特异性抗肿瘤活性。其不同细胞效应的分子机制已被详细研究，并已被证明在细胞内具有多个靶点和相互作用的大分子。姜黄素已被证明具有抗血管生成特性，并且姜黄素的血管抑制作用由于促血管生成基因如VEGF和血管生成素的下调以及内皮细胞的迁移和侵袭的减少而显现。涉及化学抗性和诱导的化学敏感性的重要因素之一是NFkB，并且姜黄素已显示下调N17kB并抑制IKB激酶，从而抑制增殖并诱导凋亡。对某些凋亡诱导剂和辐射具有抗性的细胞系在与姜黄素联合处理时变得对凋亡敏感。除此之外，它还可以通过抑制结肠异常隐窝灶形成和DNA加合物形成而作为结肠癌、胃癌和皮肤癌的化学预防剂。本文综述了姜黄素作为一种潜在的癌症治疗药物的各个方面及其在各种生物和细胞过程中的作用机制。
Curcumin, a natural component of the rhizome of curcuma longa has emerged as one of the most powerful chemopreventive and anticancer agents. Its biological effects range from antioxidant, anti-inflammatory to inhibition of angiogenesis and is also shown to possess specific antitumoral activity. The molecular mechanism of its varied cellular effects has been studied in some details and it has been shown to have multiple targets and interacting macromolecules within the cell. Curcumin has been shown to possess anti-angiogenic properties and the angioinhibitory effects of curcumin manifest due to down regulation of proangiogenic genes such as VEGF and angiopoitin and a decrease in migration and invasion of endothelial cells. One of the important factors implicated in chemoresistance and induced chemosensitivity is NFkB and curcumin has been shown to down regulate N17kB and inhibit IKB kinase thereby suppressing proliferation and inducing apoptosis. Cell lines that are resistant to certain apoptotic inducers and radiation become susceptible to apoptosis when treated in conjunction with curcumin. Besides this it can also act as a chernopreventive agent in cancers of colon, stomach and skin by suppressing colonic aberrant crypt foci formation and DNA adduct formation. This review focuses on the various aspects of curcumin as a potential drug for cancer treatment and its implications in a variety of biological and cellular processes vis-a-vis its mechanism of action.