A Bibliometric Insight of Genetic Factors in ASD: Emerging Trends and New Developments.
A Bibliometric Insight of Genetic Factors in ASD: Emerging Trends and New Developments.
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DOI：
10.3390/brainsci11010033
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发表时间：
2020-12-31
期刊：
影响因子：
3.3
通讯作者：
Xiong B
中科院分区：
文献类型：
--
作者：
Wang K;Duan W;Duan Y;Yu Y;Chen X;Xu Y;Chen H;Huang H;Xiong B
近几十年来，自闭症谱系障碍（ASD）病例迅速增加，这与各种遗传异常有关。为了更好地了解ASD的遗传因素，我们评估了相关研究的全球科学成果。通过对Web of Science（WoS）数据库的系统检索，共收录了1997年至2018年间发表的2944篇研究，绘制了其科学景观，并通过文献计量学方法探讨了趋势和研究前沿。近年来，美国一直是全球该领域的主要探索者。高通量技术和生物信息学的快速发展使研究方法从传统的经典方法转向基于大数据的流水线。因此，研究的重点和趋势也发生了变化，因为在过去的几年里，ASD的从头突变的贡献一直是研究热点，并可能在不久的将来仍然是一个热点，这与目前ASD主要病因的观点是一致的。因此，应给予更多的关注和财政支持，在ASD的从头突变的破译。同时，在下一步的科学研究中，应提倡多研究中心和不同领域科学家的有效合作。
Autism spectrum disorder (ASD) cases have increased rapidly in recent decades, which is associated with various genetic abnormalities. To provide a better understanding of the genetic factors in ASD, we assessed the global scientific output of the related studies. A total of 2944 studies published between 1997 and 2018 were included by systematic retrieval from the Web of Science (WoS) database, whose scientific landscapes were drawn and the tendencies and research frontiers were explored through bibliometric methods. The United States has been acting as a leading explorer of the field worldwide in recent years. The rapid development of high-throughput technologies and bioinformatics transferred the research method from the traditional classic method to a big data-based pipeline. As a consequence, the focused research area and tendency were also changed, as the contribution of de novo mutations in ASD has been a research hotspot in the past several years and probably will remain one into the near future, which is consistent with the current opinions of the major etiology of ASD. Therefore, more attention and financial support should be paid to the deciphering of the de novo mutations in ASD. Meanwhile, the effective cooperation of multi-research centers and scientists in different fields should be advocated in the next step of scientific research undertaken.
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影响因子：
30.8
作者：
Durand, Christelle M.;Betancur, Catalina;Bourgeron, Thomas
通讯作者：
Bourgeron, Thomas
影响因子：
30.8
作者：
Kircher, Martin;Witten, Daniela M.;Jain, Preti;O'Roak, Brian J.;Cooper, Gregory M.;Shendure, Jay
通讯作者：
Shendure, Jay
DOI：
10.1073/pnas.0307513100
发表时间：
2004-04-06
影响因子：
11.1
作者：
Chen, CM
通讯作者：
Chen, CM
影响因子：
6.8
作者：
Drakesmith, Mark;Parker, Greg D.;Linden, David E. J.
通讯作者：
Linden, David E. J.
影响因子：
30.8
作者：
Cooper, Gregory M.;Coe, Bradley P.;Eichler, Evan E.
通讯作者：
Eichler, Evan E.