Vitamins D, C, and E in the prevention of type 2 diabetes mellitus: modulation of inflammation and oxidative stress.
Vitamins D, C, and E in the prevention of type 2 diabetes mellitus: modulation of inflammation and oxidative stress.
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DOI：
10.2147/btt.s14417
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Badawi A
中科院分区：
文献类型：
--
作者：
Garcia-Bailo B;El-Sohemy A;Haddad PS;Arora P;Benzaied F;Karmali M;Badawi A
2 型糖尿病 (T2DM) 的发病率在全球范围内不断增加，某些人群特别容易感染该疾病。为了降低人群层面的 T2DM 风险和进展，需要能够以最小的成本和精力在人群范围内实施的预防策略。由氧化应激和先天免疫系统失衡引起的慢性低度炎症与肥胖、代谢综合征和胰岛素抵抗有关，这些是 T2DM 发生和进展的关键阶段。因此，炎症可能在 T2DM 的发病机制中发挥因果作用，通过调节氧化应激和先天免疫反应来减少炎症可能会导致胰岛素敏感性改善和疾病发作延迟。膳食补充抗炎和抗氧化营养因子（例如微量营养素）可能为在人群水平上预防和控制 T2DM 提供一种新策略。这篇综述探讨了氧化、炎症信号通路以及维生素补充或摄入与 T2DM 风险之间联系的最新知识。微量营养素可以通过减轻炎症作为 T2DM 的一种新型预防措施，这一概念在其与公共卫生的相关性背景下进行了评估。
The incidence of type 2 diabetes mellitus (T2DM) is increasing worldwide, and certain population subgroups are especially vulnerable to the disease. To reduce T2DM risk and progression at the population level, preventative strategies are needed that can be implemented on a population-wide scale with minimal cost and effort. Chronic low-grade inflammation resulting from oxidative stress and imbalances in the innate immune system has been associated with obesity, metabolic syndrome, and insulin resistance – critical stages in the development and progression of T2DM. Therefore, inflammation may play a causal role in the pathogenesis of T2DM, and reducing it via modulation of oxidative stress and the innate immune response could lead to a status of improved insulin sensitivity and delayed disease onset. Dietary supplementation with anti-inflammatory and antioxidant nutritional factors, such as micronutrients, might present a novel strategy toward the prevention and control of T2DM at the population level. This review examines current knowledge linking oxidation, inflammatory signaling pathways, and vitamin supplementation or intake to the risk of T2DM. The concept that micronutrients, via attenuation of inflammation, could be employed as a novel preventive measure for T2DM is evaluated in the context of its relevance to public health.