Vasoactive intestinal peptide causes marked cephalic vasodilation, but does not induce migraine
Vasoactive intestinal peptide causes marked cephalic vasodilation, but does not induce migraine
复制标题
DOI：
10.1111/j.1468-2982.2007.01497.x
复制
发表时间：
2008-03-01
期刊：
影响因子：
4.9
通讯作者：
Ashina, M.
中科院分区：
文献类型：
--
作者：
Rahmann, A.;Wienecke, T.;Ashina, M.
我们假设静脉输注副交感神经递质血管活性肠肽（VIP）可能诱发偏头痛患者的偏头痛发作。在一项随机、双盲交叉研究中，12名无先兆偏头痛患者被分配接受8 pmol kg(-1) min(-1) VIP或安慰剂。采用口头评定量表（VRS）对头痛进行评分，经颅多普勒超声测量大脑中动脉平均血流速度（V-mean MCA），高频超声测量颞浅动脉直径（STA）。在VIP输注后，没有受试者报告偏头痛发作。与安慰剂相比，VIP引起轻度即刻头痛（VRS组最大2例）（P = 0.005）。VIP治疗组3例报告延迟性头痛（输液后3 ~ 11 h），安慰剂治疗组2例报告延迟性头痛（P = 0.89）。V-mean MCA降低（16.3 +/- 5.9%），STA直径显著增加（45.9 +/- 13.9%）。VIP介导明显的颅动脉扩张，但不会引发偏头痛患者的偏头痛发作。这些数据提供了进一步的证据，反对偏头痛的纯粹血管起源。
We hypothesized that intravenous infusion of the parasympathetic transmitter, vasoactive intestinal peptide (VIP), might induce migraine attacks in migraineurs. Twelve patients with migraine without aura were allocated to receive 8 pmol kg(-1) min(-1) VIP or placebo in a randomized, double-blind crossover study. Headache was scored on a verbal rating scale (VRS), mean blood flow velocity in the middle cerebral artery (V-mean MCA) was measured by transcranial Doppler ultrasonography, and diameter of the superficial temporal artery (STA) by high-frequency ultrasound. None of the subjects reported a migraine attack after VIP infusion. VIP induced a mild immediate headache (maximum 2 on VRS) compared with placebo (P = 0.005). Three patients reported delayed headache (3-11 h after infusion) after VIP and two after placebo (P = 0.89). V-mean MCA decreased (16.3 +/- 5.9%) and diameter of STA increased significantly after VIP (45.9 +/- 13.9%). VIP mediates a marked dilation of cranial arteries, but does not trigger migraine attacks in migraineurs. These data provide further evidence against a purely vascular origin of migraine.