Variation of Stratum Corneum Biophysical and Molecular Properties with Anatomic Site
Variation of Stratum Corneum Biophysical and Molecular Properties with Anatomic Site
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DOI：
10.1208/s12248-012-9400-3
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发表时间：
2012-12-01
期刊：
影响因子：
4.5
通讯作者：
Lane, Majella E.
中科院分区：
文献类型：
--
作者：
Mohammed, Diar;Matts, Paul J.;Lane, Majella E.
已知几种丝氨酸蛋白酶参与皮肤的正常脱屑和炎症过程。这些蛋白酶活性的改变也会影响角质层的成熟度和大小以及角质层的厚度。本研究的目的是描述角质层细胞大小、角质层细胞成熟度、选定蛋白酶活性（特别是钾化钾素-5和7、胰蛋白酶）、蛋白质含量和表皮水分流失（TEWL）作为解剖部位功能的基线变化。研究的解剖部位为：脸颊、腹部、手腕和前臂正中腹侧。TEWL值最高的是脸颊(p
Several serine protease enzymes are known to be involved in both normal desquamation and the inflammatory processes of the skin. Alteration in the activity of these proteases should also affect corneocyte maturity and size as well as stratum corneum thickness. The aim of the present work was to characterise the baseline changes in corneocyte size, corneocyte maturity, selected protease activity (specifically, Kallikreins-5 and 7, tryptase), protein content and trans-epidermal water loss (TEWL) as a function of anatomic site. The anatomic sites investigated were: cheek, abdomen, wrist and mid-ventral forearm. TEWL values were highest for the cheek (p