PROTECTION OF MICE AGAINST FATAL HERPES-SIMPLEX TYPE-2 INFECTION BY LIPOSOMES CONTAINING MURAMYL TRIPEPTIDE
PROTECTION OF MICE AGAINST FATAL HERPES-SIMPLEX TYPE-2 INFECTION BY LIPOSOMES CONTAINING MURAMYL TRIPEPTIDE
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DOI：
10.1126/science.2984772
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发表时间：
1985-01-01
期刊：
影响因子：
56.9
通讯作者：
FIDLER, IJ
中科院分区：
文献类型：
--
作者：
KOFF, WC;SHOWALTER, SD;FIDLER, IJ
I.v. administration of liposomes containing muramyl tripeptide phosphatidylethanolamine, a lipophilic derivative of muramyl dipeptide that activates macrophages to a cytolytic state in situ, significantly protected mice against lethal challenge with herpes simplex virus type 2. The systemic activation of macrophages by liposomes containing an immunomodulator evidently can lead to prophylaxis of severe infections caused by hypesviruses.
