Concurrent modified PCV chemotherapy and radiotherapy in newly diagnosed grade IV astrocytoma
Concurrent modified PCV chemotherapy and radiotherapy in newly diagnosed grade IV astrocytoma
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DOI：
10.1023/a:1015797713149
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发表时间：
2002-05-01
影响因子：
3.9
通讯作者：
Thiessen, B
中科院分区：
文献类型：
--
作者：
Murphy, C;Pickles, T;Thiessen, B
辅助化疗（CT）治疗IV级星形细胞瘤最多是适度有效的。CT的放射增敏作用可能比同时放疗（RT）和CT更有优势。方法：1992 ~ 1997年，对1992 ~ 1997年诊断为IV级星形细胞瘤（Daumas-Duport分级标准）、KPS>70分、年龄<10岁的患者行CT检查，并与同期行丙卡巴肼、洛莫司汀和长春新碱（PCV）治疗的患者进行比较。
Adjuvant chemotherapy (CT) in the treatment of grade IV astrocytoma is at best modestly effective. The radiosensitizing effect of CT may confer an advantage to concurrent radiotherapy (RT) and CT. This study investigated concurrent procarbazine, lomustine, and vincristine (PCV) CT in newly diagnosed grade IV astrocytoma patients.Methods: From 1992 to 1997, patients diagnosed with grade IV astrocytoma (Daumas-Duport criteria), Karnofsky performance score (KPS) >70 and age