Characterisation of Sxa2, a protease involved in pheromone communication in fission yeast.
Characterisation of Sxa2, a protease involved in pheromone communication in fission yeast.
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DOI：
10.1042/bst023565s
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发表时间：
1995-11-01
影响因子：
3.9
通讯作者：
Davey, J
中科院分区：
文献类型：
--
作者：
Ladds, G;Rasmussen, M;Davey, J
裂殖酵母以两种交配类型(正负交配)中的一种存在，两个单倍体细胞之间的接合涉及基于可扩散交配因子的相互作用的通信系统，每种交配类型的细胞释放信息素，诱导相反交配类型的细胞发生交配特有的变化[参见I]。因此，P细胞释放P因子并对M因子作出反应，因为它表达M因子受体，而M细胞则释放M因子并对P因子作出反应。暴露在信息素下会导致基因转录模式的改变，细胞生长的GI停滞，细胞的单向伸长形成shmoo。M-因子是一种翻译后修饰的九肽，其羧基末端的半胱氨酸残基既被S法尼化又被羧甲基化[2]。P因子是一个由23个残基组成的未经修饰的多肽(图1)[3]。
The fission yeast Schizosacchuromyces pombe exists in one of two mating types (Plus or Minus) and conjugation between two haploid cells involves a communication system based on the reciprocal action of diffusible mating factors, cells of each mating type releasing pheromones which induce mating-specific changes in cells of the opposite mating type [for review, see I]. Thus a P cell releases P-factor and responds to M-factor since it expresses the M-factor receptor while an M cell releases M-factor and responds to P-factor. Exposure to pheromone causes a change in the pattern of gene transcription, a GI arrest of cell growth and the unidirectional elongation of the cell to form a shmoo. M-factor is a post-translationally modified nonapeptide in which the carboxy-terminal cysteine residue is both S-farnesylated and carboxymethylated [2]. P-factor is an unmodified peptide of 23 residues (Figure 1)[3].